(Q48590280)

English

A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains.

scientific article published in October 1997

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains. (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

substantia nigra

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Naoi M

1

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

Maruyama W

2

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

Matsubara K

3

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

Hashizume Y

4

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

language of work or name

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publication date

1 October 1997

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

Neuroscience Letters

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

235

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

1-2

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

81-84

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

Role of N-methyltransferases in the neurotoxicity associated with the metabolites of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and other 4-substituted pyridines present in the environment.

1 reference

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N-methylation of pyridines in Parkinson's disease

1 reference

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7 January 2021

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A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in parkinsonian cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

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Dopamine-derived 1-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: in vivo and in vitro studies

1 reference

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7 January 2021

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N-methyl(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity

1 reference

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7 January 2021

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N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.

1 reference

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7 January 2021

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An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

based on heuristic

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A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brai

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of 1,2(N)-dimethyl-6,7-dihydroxy-isoquinolinium ion to melanin: effects of ferrous and ferric ion on the binding

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Alkaloids in mammalian tissues. 2. Synthesis of (+)- and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3940%2897%2900723-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0304-3940(97)00723-4

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9389601

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