(Q48590464)

13 February 2018

title

Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core (English)

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13 February 2018

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Alex K Lyashchenko

1

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13 February 2018

Kacy J Redd

series ordinal

2

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13 February 2018

Jay Yang

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3

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13 February 2018

Gareth R Tibbs

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4

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13 February 2018

language of work or name

English

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publication date

14 June 2007

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13 February 2018

published in

Journal of Physiology

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13 February 2018

volume

583

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13 February 2018

issue

Pt 1

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13 February 2018

page(s)

37-56

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13 February 2018

Integrated allosteric model of voltage gating of HCN channels

cites work

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Pore-to-gate coupling of HCN channels revealed by a pore variant that contributes to gating but not permeation

21 January 2018

1 reference

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Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels

21 January 2018

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Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers

21 January 2018

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Cardiac HCN channels: structure, function, and modulation

21 January 2018

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Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.

21 January 2018

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Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons

21 January 2018

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HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currents.

21 January 2018

1 reference

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Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide

21 January 2018

1 reference

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Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

CNG and HCN channels: two peas, one pod.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Cooperative gating between single HCN pacemaker channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Propofol suppresses a hyperpolarization-activated inward current in rat hippocampal CA1 neurons

21 January 2018

1 reference

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Interaction of the pacemaker channel HCN1 with filamin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Suppression of the hyperpolarization-activated inward current contributes to the inhibitory actions of propofol on rat CA1 and CA3 pyramidal neurons

21 January 2018

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Sleep and arousal: thalamocortical mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties

21 January 2018

1 reference

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Modulation of the hyperpolarization-activated cation current of rat thalamic relay neurones by intracellular pH.

21 January 2018

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Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2

21 January 2018

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Hyperpolarization-activated cation currents: from molecules to physiological function

21 January 2018

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The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels

21 January 2018

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Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Multiple ionic mechanisms mediate inhibition of rat motoneurones by inhalation anaesthetics

21 January 2018

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Error estimates for results of nonstationary noise analysis derived with linear least squares methods

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Thalamocortical oscillations in the sleeping and aroused brain

21 January 2018

1 reference

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Mechanisms of propofol action on ion currents in the myelinated axon of Xenopus laevis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Pacemaking by HCN channels requires interaction with phosphoinositides

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

Characterization of single pacemaker channels in cardiac sino-atrial node cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2007.136465

HCN pacemaker channel activation is controlled by acidic lipids downstream of diacylglycerol kinase and phospholipase A2

21 January 2018

1 reference

12 December 2020

Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry

1 reference

12 December 2020

Nonstationary noise analysis and application to patch clamp recordings

1 reference

12 December 2020

Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node

1 reference

12 December 2020

10.1113/JPHYSIOL.2007.136465

Identifiers

DOI

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13 February 2018

PMC publication ID

2277223

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1 reference

13 February 2018