(Q48672025)

14 February 2018

title

Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider delta-atracotoxin (English)

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14 February 2018

author

Graham M Nicholson

5

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14 February 2018

author name string

Nicolas Gilles

1

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14 February 2018

Greg Harrison

2

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14 February 2018

Izhar Karbat

3

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14 February 2018

Michael Gurevitz

4

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14 February 2018

Dalia Gordon

6

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14 February 2018

language of work or name

English

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publication date

1 March 2002

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14 February 2018

published in

FEBS Journal

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14 February 2018

volume

269

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14 February 2018

issue

5

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14 February 2018

page(s)

1500-1510

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14 February 2018

The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider

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Structure-function studies of omega-atracotoxin, a potent antagonist of insect voltage-gated calcium channels

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Isolation of a funnel-web spider polypeptide with homology to mamba intestinal toxin 1 and the embryonic head inducer Dickkopf-1.

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Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge

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Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.

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Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation

21 January 2018

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Isolation and pharmacological characterisation of delta-atracotoxin-Hv1b, a vertebrate-selective sodium channel toxin

21 January 2018

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Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus

21 January 2018

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The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel

21 January 2018

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Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus

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A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides

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Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin

21 January 2018

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Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves

21 January 2018

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Orthorhombic crystals and three-dimensional structure of the potent toxin II from the scorpion Androctonus australis Hector

21 January 2018

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Solution structures of a highly insecticidal recombinant scorpion alpha-toxin and a mutant with increased activity

21 January 2018

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Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A

21 January 2018

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A new approach to insect-pest control--combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity.

21 January 2018

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Molecular properties of voltage-sensitive sodium channels

21 January 2018

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New toxins acting on sodium channels from the scorpion Leiurus quinquestriatus hebraeus suggest a clue to mammalian vs insect selectivity.

21 January 2018

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Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels

21 January 2018

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delta-Atracotoxins from australian funnel-web spiders compete with scorpion alpha-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels

21 January 2018

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Functional expression and genetic alteration of an alpha scorpion neurotoxin.

21 January 2018

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Active transport of gamma-aminobutyric acid by membrane vesicles isolated from rat brain

21 January 2018

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NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus

21 January 2018

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Sodium channel polypeptides in central nervous systems of various insects identified with site directed antibodies

21 January 2018

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Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels.

21 January 2018

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Structural implications on the interaction of scorpion alpha-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding.

21 January 2018

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

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Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

21 January 2018

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Two types of scorpion neurotoxins characterized by their binding to two separate receptor sites on rat brain synaptosomes

21 January 2018

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Effect of depolarization on binding kinetics of scorpion alpha-toxin highlights conformational changes of rat brain sodium channels

21 January 2018

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Membrane potentials in pinched-off presynaptic nerve ternimals monitored with a fluorescent probe: evidence that synaptosomes have potassium diffusion potentials

21 January 2018

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Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

21 January 2018

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Tissue-specific expression of the RI and RII sodium channel subtypes

21 January 2018

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Identification of structural elements of a scorpion alpha-neurotoxin important for receptor site recognition.

21 January 2018

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Diversification of neurotoxins by C-tail 'wiggling': a scorpion recipe for survival

21 January 2018

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A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure, and mode of action

21 January 2018

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Binding of an alpha scorpion toxin to insect sodium channels is not dependent on membrane potential

21 January 2018

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

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Functional Anatomy of Scorpion Toxins Affecting Sodium Channels

21 January 2018

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Complete amino acid sequence of a new type of lethal neurotoxin from the venom of the funnel-web spider Atrax robustus

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02799.X

Alpha-scorpion toxins binding on rat brain and insect sodium channels reveal divergent allosteric modulations by brevetoxin and veratridine

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02799.X

Depolarization differentially affects allosteric modulation by neurotoxins of scorpion alpha-toxin binding on voltage-gated sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02799.X

Membrane potential dependent binding of scorpion toxin to the action potential sodium ionophore. Studies with a 3-(4-hydroxy 3-[125I] iodophenyl) propionyl derivative

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02799.X

Scorpion alpha and alpha-like toxins differentially interact with sodium channels in mammalian CNS and periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1033.2002.02799.X

10.1046/J.1432-1033.2002.02799.X

21 January 2018

Identifiers

DOI

1 reference

14 February 2018

1 reference

14 February 2018