(Q48680605)

14 February 2018

title

Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation. (English)

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14 February 2018

main subject

peloruside A

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ChEBI release 2020-05-28

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Viswanath Das

1

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14 February 2018

John H Miller

series ordinal

2

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14 February 2018

language of work or name

English

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publication date

17 May 2012

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14 February 2018

European Journal of Neuroscience

published in

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14 February 2018

volume

35

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14 February 2018

issue

11

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14 February 2018

page(s)

1705-1717

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14 February 2018

The use of okadaic acid in vivo and the induction of molecular changes typical for Alzheimer's disease.

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+ -induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Molecular mechanisms, biological actions, and neuropharmacology of the growth-associated protein GAP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Substoichiometric binding of taxol suppresses microtubule dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

A unique mode of microtubule stabilization induced by peloruside A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Discodermolide interferes with the binding of tau protein to microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Method for serum-free culture of late fetal and early postnatal rat brainstem neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Microtubule acetylation promotes kinesin-1 binding and transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Signalling mechanisms regulating axonal branching in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Microtubule stabilization specifies initial neuronal polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Attenuation of okadaic acid-induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2012.08084.X

10.1111/J.1460-9568.2012.08084.X

21 January 2018

Identifiers

DOI

1 reference

14 February 2018

PubMed ID

22594877

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14 February 2018