(Q48700948)

English

On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.

scientific article published in January 2006

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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Brian W. Ogilvie

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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Andrew Parkinson

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Neda Leonard

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Alison Draper

3

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Europe PubMed Central

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21 January 2020

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1 January 2006

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21 January 2020

Drug Metabolism Reviews

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

38

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21 January 2020

1-2

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21 January 2020

235-259

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Psychotropic drugs: Evaluation of mutagenic effect

1 reference

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21 January 2018

PPARs: therapeutic targets for metabolic disease

1 reference

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21 January 2018

Biliary Excretion of Conjugated Hydroxyl Benzodiazepines after Administration of Several Benzodiazepines to Rats, Guinea Pigs, and Mice

1 reference

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21 January 2018

Proceedings in uncovering the mechanism behind peroxisome proliferator-induced hepatocarcinogenesis

1 reference

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21 January 2018

Carcinogenicity studies of oxazepam in mice

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Early responses of the liver of B6C3F1 mice to the hepatocarcinogen oxazepam.

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Carcinogenesis bioassay of prazepam (Verstran) in rats and mice.

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet

1 reference

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21 January 2018

Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver

1 reference

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21 January 2018

Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver

1 reference

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21 January 2018

Role of persistent, non-genotoxic tissue damage in rodent cancer and relevance to humans

1 reference

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21 January 2018

Self-reported use of antidepressants or benzodiazepine tranquilizers and risk of epithelial ovarian cancer: evidence from two combined case-control studies (Massachusetts, United States).

1 reference

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21 January 2018

Effect of diazepam on hepatocarcinogenesis in the rat.

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

PPARalpha agonist-induced rodent tumors: modes of action and human relevance

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Rodent carcinogenicity of peroxisome proliferators and issues on human relevance

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Quantitative determination of cytochrome P-450 in rat liver homogenate

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Cancer in children of epileptic mothers and the possible relation to maternal anticonvulsant therapy

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Cancer among epileptic patients exposed to anticonvulsant drugs

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Growth characteristics and Ha-ras mutations of cell cultures isolated from chemically induced mouse liver tumours

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Investigation, with the Salmonella/microsome test, of psychopharmaceuticals used in meat production.

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Lack of initiating or promoting activity of six benzodiazepine tranquilizers in rat liver limited bioassays monitored by histopathology and assay of liver and plasma enzymes

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Cancer risk in people with epilepsy: the role of antiepileptic drugs

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Degradation of cytochrome P450 2E1: Selective loss after labilization of the enzyme

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Purification of two isozymes of rat liver microsomal cytochrome P450 with testosterone 7 alpha-hydroxylase activity

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P450

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Activity of hepatic drug metabolizing enzymes following oxazepam-dosed feed treatment in B6C3F1 mice

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Biochemical effects of the mouse hepatocarcinogen oxazepam: similarities to phenobarbital

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Partial purification of cytochromes P-450 and P-448 from rat liver microsomes

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Production and purification of antibodies against rat liver P450 enzymes

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Determination of microsomal lauric acid hydroxylase activity by HPLC with flow-through radiochemical quantitation

1 reference

https://api.crossref.org/works/10.1080%2F03602530600570081

21 January 2018

Identifiers

10.1080/03602530600570081

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16684660%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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