(Q48764920)

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Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. I. Taxonomy, fermentation, isolation and biological activities.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9918391%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. I. Taxonomy, fermentation, isolation and biological activities (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9918391%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

Thermobifida alba

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[(2R)-1-amino-3-[(3S,6S,13S,14R)-6,13-dimethyl-10-methylidene-2,5,9,12-tetraoxo-14-[(3R,5E,7E,10S)-3,7,10-trimethyl-4-oxoheptadeca-5,7-dienyl]-1-oxa-4,8,11-triazacyclotetradec-3-yl]-1-oxopropan-2-yl] hydrogen sulfate

1 reference

[(2S)-1-amino-3-[(3R,6R,13R,14S)-6,13-dimethyl-10-methylidene-2,5,9,12-tetraoxo-14-[(3S,5E,7E,10R)-3,7,10-trimethyl-4-oxoheptadeca-5,7-dienyl]-1-oxa-4,8,11-triazacyclotetradec-3-yl]-1-oxopropan-2-yl] hydrogen sulfate

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author name string

K Suzuki

1

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9 December 2019

K Nagao

2

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9 December 2019

Y Monnai

3

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9 December 2019

A Yagi

4

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9 December 2019

M Uyeda

5

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9 December 2019

publication date

1998

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16 September 2022

16 September 2022

full work available at URL

https://www.jstage.jst.go.jp/article/antibiotics1968/51/11/51_11_991/_pdf

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The Journal of Antibiotics

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9 December 2019

51

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9 December 2019

11

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9 December 2019

991-998

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9 December 2019

online access status

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access restriction status

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CJ-12,373, a novel topoisomerase II inhibitor: fermentation, isolation, structure elucidation and biological activities

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Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

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Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.

1 reference

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1513-DMIa and 1513-DMIb, DNA methyltransferase inhibitors produced by Streptomyces sp. strain No. 1513

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DNA topoisomerases

1 reference

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Purification and characterization of DNA topoisomerase II from calf thymus associated with polypeptides of 175 and 150 kDa.

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DMI-2 and DMI-3, DNA methyltransferase inhibitors produced by Streptomyces sp. strain no. 560

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Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

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Topoisomerase-targeting antitumor drugs

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Inhibition of DNA methyltransferase by microbial inhibitors and fatty acids.

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Inhibition of DNA topoisomerases by microbial inhibitors

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Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus

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5838-DNI, A Deoxyribonuclease Inhibitor Produced byStreptomycesSp. Strain No. A-5838

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Deoxyribonuclease inhibitors produced by streptomycetes

1 reference

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DMI-1, a new DNA methyltransferase inhibitor produced by Streptomyces sp. strain No. 560

1 reference

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Structure of RNA polymerase II promoters. Conformational alterations and template properties of circularized Saccharomyces cerevisiae GAL1-GAL10 divergent promoters.

1 reference

12 April 2024

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Identifiers

10.7164/ANTIBIOTICS.51.991

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9918391%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

1 reference

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9 December 2019

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