(Q48823573)

English

Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway.

scientific article published in January 1997

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scholarly article

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/8987738

Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

Laurent Journot

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

Martin Villalba

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

author name string

J Bockaert

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

language of work or name

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publication date

1 January 1997

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/8987738

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

17

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

83-90

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of dibutyryl cyclic AMP and retinoic acid on the differentiation of dopamine neurons: prevention of cell death by dibutyryl cyclic AMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by cAMP of Ras-dependent activation of Raf.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of non-N-methyl-D-aspartate receptors in cultured cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor withdrawal induces the apoptotic death of developing septal cholinergic neurons in vitro: protection by cyclic AMP analogue and high potassium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The death programme in cultured sympathetic neurones can be suppressed at the posttranslational level by nerve growth factor, cyclic AMP, and depolarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear changes in apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasoactive intestinal peptide regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding sites of a novel neuropeptide pituitary-adenylate-cyclase-activating polypeptide in the rat brain and lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific and developmental expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential signal transduction by five splice variants of the PACAP receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

38-Amino acid form of pituitary adenylate cyclase activating peptide induces process outgrowth in human neuroblastoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating peptide stimulates neurite growth in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase. Comparison with the effects of insulin, growth factors and phorbol esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization and characterization of PACAP receptors in the rat cerebellum during development: evidence for a stimulatory effect of PACAP on immature cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A highly sensitive adenylate cyclase assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylyl cyclase and phospholipase C activity in rat cerebellar neuroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 38-amino acid form of pituitary adenylate cyclase-activating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase activating polypeptide provokes cultured rat chromaffin cells to secrete adrenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The VIP2 receptor: molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACAP functions as a neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties and distribution of receptors for pituitary adenylate cyclase activating peptide (PACAP) in rat brain and spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of p44 and p42 MAP kinases is not essential for the survival of rat sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide activates different signal transducing mechanisms in cultured cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing cAMP attenuates activation of mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca(2+)-dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptor subtypes in clonal pituitary somatotrophs and gonadotrophs

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/8987738

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.17-01-00083.1997

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6793681&resulttype=core&format=json

12 May 2020

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