(Q48918632)

16 February 2018

title

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter. (English)

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16 February 2018

amyotrophic lateral sclerosis

main subject

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author

Niels Christian Danbolt

3

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16 February 2018

author name string

D Trotti

1

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16 February 2018

A Rolfs

2

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16 February 2018

R H Brown

4

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16 February 2018

M A Hediger

5

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16 February 2018

language of work or name

English

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publication date

1 May 1999

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16 February 2018

published in

Nature Neuroscience

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16 February 2018

volume

2

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16 February 2018

issue

5

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16 February 2018

page(s)

427-433

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16 February 2018

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

cites work

1 reference

7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

7 January 2021

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superox

1 reference

7 January 2021

Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.

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7 January 2021

Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis

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7 January 2021

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

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7 January 2021

Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.

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7 January 2021

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

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7 January 2021

A familial amyotrophic lateral sclerosis-associated A4V Cu, Zn-superoxide dismutase mutant has a lower Km for hydrogen peroxide. Correlation between clinical severity and the Km value.

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7 January 2021

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

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7 January 2021

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

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7 January 2021

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

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7 January 2021

Brain glutamate transporter proteins form homomultimers

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7 January 2021

The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain

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7 January 2021

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

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7 January 2021

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

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7 January 2021

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

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7 January 2021

Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis

1 reference

7 January 2021

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

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7 January 2021

Glutamate uptake is decreased tardively in the spinal cord of FALS mice

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7 January 2021

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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7 January 2021

Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

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7 January 2021

Peroxynitrite inhibits glutamate transporter subtypes

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7 January 2021

Differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1.

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7 January 2021

Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

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7 January 2021

Cu/Zn superoxide dismutase activity in familial and sporadic amyotrophic lateral sclerosis

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7 January 2021

Genetics of amyotrophic lateral sclerosis

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7 January 2021

Flux coupling in a neuronal glutamate transporter

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7 January 2021

Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology

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7 January 2021

Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury

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7 January 2021

A potent superoxide dismutase mimic: manganese beta-octabromo-meso-tetrakis-(N-methylpyridinium-4-yl) porphyrin

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7 January 2021

Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

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7 January 2021

Amyotrophic lateral sclerosis is a multifactorial disease

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7 January 2021

Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice

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7 January 2021

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

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7 January 2021

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

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7 January 2021

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

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Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis

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Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

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7 January 2021

Identifiers

DOI

10.1038/8091

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16 February 2018

release_h4ui4znrhffplealo5ue22hcw4

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/h4ui4znrhffplealo5ue22hcw4

24 November 2022

mapped directly with Wikidata item

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16 February 2018