(Q48919619)

16 February 2018

title

Selective contribution of interleukin-6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice. (English)

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16 February 2018

author name string

Christoph Rummel

1

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16 February 2018

Wataru Inoue

2

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16 February 2018

Christelle Sachot

3

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16 February 2018

Stephen Poole

4

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16 February 2018

Thomas Hübschle

5

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16 February 2018

Giamal N Luheshi

6

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16 February 2018

language of work or name

English

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publication date

1 November 2008

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16 February 2018

The Journal of Comparative Neurology

published in

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16 February 2018

volume

511

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16 February 2018

issue

3

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16 February 2018

page(s)

373-395

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16 February 2018

Selected contribution: role of IL-6 in LPS-induced nuclear STAT3 translocation in sensory circumventricular organs during fever in rats

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COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production

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Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB.

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A role for cyclooxygenase-2 in lipopolysaccharide-induced anorexia in rats

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Activation of 5-HT1A receptors in raphe pallidus inhibits leptin-evoked increases in brown adipose tissue thermogenesis

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Regulation of matrix metalloproteinases and their inhibitor genes in lipopolysaccharide-induced endotoxemia in mice

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Fever induction by localized subcutaneous inflammation in guinea pigs: the role of cytokines and prostaglandins

21 January 2018

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Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain.

21 January 2018

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Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3.

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7 January 2021

IL-6-regulated transcription factors

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7 January 2021

IMPAIRED STAT3 ACTIVATION FOLLOWING LOCALIZED INFLAMMATORY STIMULUS IN IL-6-DEFICIENT MICE

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7 January 2021

The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues

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7 January 2021

Leptin binding in the arcuate nucleus is increased during fasting

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7 January 2021

Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice

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7 January 2021

Divergent signaling capacities of the long and short isoforms of the leptin receptor

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7 January 2021

Expression of leptin receptor isoforms in rat brain microvessels

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7 January 2021

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

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7 January 2021

Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency

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7 January 2021

Leptin stimulates prostaglandin E2 and F2alpha, but not nitric oxide production in neonatal rat hypothalamus.

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7 January 2021

Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter

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7 January 2021

Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever

1 reference

7 January 2021

Early developmental expression of leptin receptor gene and [125I]leptin binding in the rat forebrain

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7 January 2021

Circulating interleukin-6 mediates the febrile response to localised inflammation in rats

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7 January 2021

Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat.

1 reference

7 January 2021

Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice

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7 January 2021

Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines.

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7 January 2021

Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells

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7 January 2021

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7 January 2021

Regional localization of specific [125I]leptin binding sites in rat forebrain.

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7 January 2021

Triggering of Toll-like receptors modulates IFN-gamma signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling

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7 January 2021

Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells

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7 January 2021

Chemical characterization of leptin-activated neurons in the rat brain

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7 January 2021

Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration

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7 January 2021

Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages.

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7 January 2021

Differential accessibility of circulating leptin to individual hypothalamic sites

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7 January 2021

Defective inflammatory response in interleukin 6-deficient mice

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7 January 2021

Intracellular signalling pathways activated by leptin

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7 January 2021

Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge

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7 January 2021

Characterization of STAT3-expressing cells in the postnatal rat brain.

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7 January 2021

Role of nitric oxide in lipopolysaccharide-induced release of vasopressin in rats

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7 January 2021

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels

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7 January 2021

Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice: effect of LPS on plasma leptin and adiponectin concentrations

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7 January 2021

Differential expression of mRNA for leptin receptor isoforms in the rat brain

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7 January 2021

Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus

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7 January 2021

Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior.

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7 January 2021

Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA.

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7 January 2021

Interleukin-6 mediates lipopolysaccharide-induced nuclear STAT3 translocation in astrocytes of rat sensory circumventricular organs

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7 January 2021

Leptin receptor immunoreactivity is present in ascending serotonergic and catecholaminergic neurons of the rat.

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7 January 2021

Leptin affects the electrical activity of neurones in the hypothalamic supraoptic nucleus

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7 January 2021

Brain stem is a direct target for leptin's action in the central nervous system

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7 January 2021

Bacterial endotoxin induces STAT3 activation in the mouse brain

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7 January 2021

Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation.

1 reference

7 January 2021

Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin

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7 January 2021

Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice

1 reference

7 January 2021

Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain.

1 reference

7 January 2021

Effects of leptin on endothelial function with OB-Rb gene transfer in Zucker fatty rats

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7 January 2021

Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia

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7 January 2021

Endothelial cells require STAT3 for protection against endotoxin-induced inflammation

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7 January 2021

Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain

1 reference

7 January 2021

Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli

1 reference

7 January 2021

IL-6 and IL-1 beta in fever. Studies using cytokine-deficient (knockout) mice

1 reference

7 January 2021

Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain

1 reference

7 January 2021

Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components

1 reference

7 January 2021

Adipokines as emerging mediators of immune response and inflammation.

1 reference

7 January 2021

Anorexia of infection: current prospects

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7 January 2021

Verapamil and indomethacin attenuate endotoxin-induced anorexia.

1 reference

7 January 2021

The unique characteristics of inflammatory responses in mouse brain are acquired during postnatal development.

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7 January 2021

The differential role of prostaglandin E2 receptors EP3 and EP4 in regulation of fever

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7 January 2021

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

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7 January 2021

Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges

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7 January 2021

Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers

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7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

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7 January 2021

The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice

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7 January 2021

Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats

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7 January 2021

Fasting increases leptin receptor mRNA expression in lean but not obese (ob/ob) mouse brain

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7 January 2021

Leptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1/signal transducer and activator of transcription 3 mechanism

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7 January 2021

Leptin actions on food intake and body temperature are mediated by IL-1

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7 January 2021

LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus

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7 January 2021

Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines

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7 January 2021

Leptin receptors in hypothalamus and circumventricular organs

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7 January 2021

Induction of Neutrophil Chemotaxis by Leptin: Crucial Role for p38 and Src Kinases

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7 January 2021

Neuroimmune response to endogenous and exogenous pyrogens is differently modulated by sex steroids.

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7 January 2021

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin

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7 January 2021

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

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7 January 2021

Cloning of rat obese cDNA and its expression in obese rats

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7 January 2021

Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain.

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7 January 2021

Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration

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7 January 2021

Leptin receptor signaling and the regulation of mammalian physiology

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7 January 2021

Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse

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7 January 2021

NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain.

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7 January 2021

The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area.

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7 January 2021

Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions.

1 reference

7 January 2021

Differential effects of selective cyclooxygenase (COX)-1 and COX-2 inhibitors on anorexic response and prostaglandin generation in various tissues induced by zymosan.

1 reference

7 January 2021

Circulating cytokines as mediators of fever

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7 January 2021

Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses

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7 January 2021

Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS

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7 January 2021

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils

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7 January 2021

Involvement of central microsomal prostaglandin E synthase-1 in IL-1beta-induced anorexia.

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7 January 2021

Development and application of radioimmunoassays for interleukin-1 alpha and interleukin-1 beta

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7 January 2021

Brain-immune communication pathways

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7 January 2021

The effects of prostaglandin E2 on the firing rate activity of thermosensitive and temperature insensitive neurons in the ventromedial preoptic area of the rat hypothalamus

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7 January 2021

Effects of prostaglandin E2 on the electrical properties of thermally classified neurons in the ventromedial preoptic area of the rat hypothalamus

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7 January 2021

Rat interleukin 6: expression in recombinant Escherichia coli, purification and development of a novel ELISA

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7 January 2021

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

1 reference

7 January 2021

Signaling the brain in systemic inflammation: role of sensory circumventricular organs

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7 January 2021

Nuclear translocation of the transcription factor STAT3 in the guinea pig brain during systemic or localized inflammation

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7 January 2021

Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6.

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7 January 2021

Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats

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7 January 2021

Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia

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7 January 2021

Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells

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7 January 2021

Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults.

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7 January 2021

Expression of the leptin receptor in different types of vascular lesions.

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7 January 2021

Identification of targets of leptin action in rat hypothalamus

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7 January 2021

TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent.

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7 January 2021

Biological action of leptin as an angiogenic factor

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7 January 2021

Leptin-target neurones of the rat hypothalamus express somatostatin receptors.

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7 January 2021

Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells

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7 January 2021

Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines

1 reference

7 January 2021

Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice

1 reference

7 January 2021

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation

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7 January 2021

Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia

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7 January 2021

Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration.

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7 January 2021

Interleukin-6-deficient mice develop mature-onset obesity

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7 January 2021

A novel leptin receptor isoform in rat.

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7 January 2021

Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice

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7 January 2021

Involvement of prostaglandin E2 released from leptomeningeal cells in increased expression of transforming growth factor-beta in glial cells and cortical neurons during systemic inflammation.

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7 January 2021

ICAM-1 induction by TNFalpha and IL-6 is mediated by distinct pathways via Rac in endothelial cells

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7 January 2021

Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever.

1 reference

7 January 2021

Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A

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7 January 2021

Centrally administered murine leptin stimulates plasma arginine-vasopressin secretion and increases the level of mRNA expression in the supraoptic nucleus of conscious rats

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7 January 2021

Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo.

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7 January 2021

Neurons of the rat preoptic area and the raphe pallidus nucleus innervating the brown adipose tissue express the prostaglandin E receptor subtype EP3.

1 reference

7 January 2021

Interleukin 1 Activates STAT3/Nuclear Factor-κB Cross-talk via a Unique TRAF6- and p65-dependent Mechanism

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7 January 2021

Positional cloning of the mouse obese gene and its human homologue

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7 January 2021

Identifiers

DOI

10.1002/CNE.21850

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16 February 2018

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16 February 2018