(Q48919818)

16 February 2018

title

Expression of presenilin-1 and Notch-1 receptor in human embryonic CNS. (English)

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16 February 2018

author name string

Kostyszyn B

1

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16 February 2018

Cowburn RF

2

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16 February 2018

Seiger A

3

1 reference

16 February 2018

KjAEldgaard A

4

1 reference

16 February 2018

Sundström E

5

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16 February 2018

language of work or name

English

0 references

publication date

1 January 2001

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16 February 2018

published in

Neuroscience

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16 February 2018

volume

103

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16 February 2018

issue

4

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16 February 2018

page(s)

885-898

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16 February 2018

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

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Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

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Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.

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Developmental regulation of presenilin mRNA expression parallels notch expression.

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

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7 January 2021

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

The suppressor of hairless protein participates in notch receptor signaling

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7 January 2021

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

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A role for Abl in Notch signaling.

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Signal transduction. Notch takes a short cut.

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Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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7 January 2021

Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation

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7 January 2021

Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.

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7 January 2021

The LIN-12/Notch signaling pathway and its regulation

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7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

A familial Alzheimer's disease locus on chromosome 1.

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7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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7 January 2021

Jagged: a mammalian ligand that activates Notch1

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7 January 2021

Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?

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7 January 2021

Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.

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7 January 2021

Embryonic and early fetal development of the human neocortex

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7 January 2021

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

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7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

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7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

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7 January 2021

Nuclear Notch1 signaling and the regulation of dendritic development

1 reference

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

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7 January 2021

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

1 reference

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

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7 January 2021

Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.

1 reference

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7 January 2021

Regional distribution of presenilin-1 messenger RNA in the embryonic rat brain: comparison with beta-amyloid precursor protein messenger RNA localization.

1 reference

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7 January 2021

Continuous network of endoplasmic reticulum in cerebellar Purkinje neurons

1 reference

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7 January 2021

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

1 reference

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7 January 2021

Complementary and combinatorial patterns of Notch gene family expression during early mouse development.

1 reference

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2801%2900045-8

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2801%2900045-8

7 January 2021

Characterization of Drosophila Presenilin and its colocalization with Notch during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2801%2900045-8

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-4522%2801%2900045-8

7 January 2021

10.1016/S0306-4522(01)00045-8

Identifiers

DOI

1 reference

16 February 2018

PubMed ID

11301199

1 reference

16 February 2018