(Q49084555)

English

Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.

scientific article published in April 2000

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5 November 2019

Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition (English)

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5 November 2019

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T Tanaka

1

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5 November 2019

I Tatsuno

2

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5 November 2019

D Uchida

3

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5 November 2019

I Moroo

4

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5 November 2019

H Morio

5

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5 November 2019

S Nakamura

6

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5 November 2019

Y Noguchi

7

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5 November 2019

T Yasuda

8

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5 November 2019

M Kitagawa

9

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5 November 2019

Y Saito

10

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5 November 2019

A Hirai

11

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5 November 2019

publication date

1 April 2000

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5 November 2019

Journal of Neuroscience

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5 November 2019

20

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5 November 2019

8

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5 November 2019

2852-2859

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5 November 2019

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1 reference

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Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

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An in vitro study of the effects of lovastatin on human fetal brain cells

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https://pubmed.ncbi.nlm.nih.gov/10751437

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Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

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Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

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Effect of neonatal malnutrition on developing cerebrum. II. Microchemical and histologic study of myelin formation in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

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based on heuristic

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Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

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based on heuristic

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Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide increase cytosolic free calcium concentration in cultured rat hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

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Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

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73-kDa heat shock cognate protein interacts directly with P27Kip1, a cyclin-dependent kinase inhibitor, during G1/S transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

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BCL-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

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bcl-2 inhibits death of central neural cells induced by multiple agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

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Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

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p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

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Lovastatin inhibits proliferation and differentiation and causes apoptosis in lipopolysaccharide-stimulated murine B cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Newly synthesized Rho A, not Ras, is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth-stimulated rat FRTL-5 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-2 blocks glutamate toxicity in neural cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mevalonate dependency of the early cell cycle mitogenic response to epidermal growth factor and prostaglandin F2 alpha in Swiss mouse 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Geranylgeranylpyrophosphate plays a key role for the G1 to S transition in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipid composition of rat brain myelin and subcellular fractions during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol biosynthesis and its regulation in dissociated cell cultures of fetal rat brain: developmental changes and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen secretion and growth of mesangial cells require geranylgeranylpyrophosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein prenyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-deficient mice are protected against adrenalectomy-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for p53-mediated modulation of neuronal viability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody highly sensitive for the detection of ras p21 in immunoblotting analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of free radicals and p53 in neuron apoptosis in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Bcl-2 in the brain-derived neurotrophic factor survival response

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of neonatal malnutrition on developing cerebrum. I. Microchemical and histologic study of cellular differentiation in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lovastatin-induced apoptosis in prostate stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of bax protein levels in neurons following cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of pravastatin in elderly versus young men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium botulinum C3 ADP-ribosyltransferase gene. Cloning, sequencing, and expression of a functional protein in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developing rat brain: changes in cholesterol, galactolipids, and the individual fatty acids of gangliosides and glycerophosphatides

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental changes in the distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase among subcellular fractions of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the mevalonate pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax involvement in p53-mediated neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-knockout mice are protected against the long-term effects of methamphetamine on dopaminergic terminals and cell bodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosine arabinoside induces apoptosis in cerebellar neurons in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 is expressed in neurons that survive focal ischemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p21 is a universal inhibitor of cyclin kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10751437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.20-08-02852.2000

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10751437%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10751437%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10751437%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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