(Q49715007)

22 February 2018

title

mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma. (English)

1 reference

22 February 2018

1 reference

Yuhua Wang

1

1 reference

22 February 2018

Lu Zhang

2

1 reference

22 February 2018

Zhenghong Xu

3

1 reference

22 February 2018

Lei Miao

4

1 reference

22 February 2018

Leaf Huang

5

1 reference

22 February 2018

publication date

21 November 2017

1 reference

22 February 2018

published in

Molecular Therapy

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22 February 2018

volume

26

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22 February 2018

issue

2

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22 February 2018

page(s)

420-434

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22 February 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5835019/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

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5 October 2018

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Nanoparticle-delivered transforming growth factor-β siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment

5 October 2018

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Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis.

5 October 2018

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5 October 2018

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5 October 2018

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5 October 2018

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5 October 2018

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PEGylation improves nanoparticle formation and transfection efficiency of messenger RNA.

5 October 2018

1 reference

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Ca2+ signaling in the regulation of dendritic cell functions

5 October 2018

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Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

5 October 2018

1 reference

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Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients

5 October 2018

1 reference

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Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity.

5 October 2018

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

5 October 2018

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Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

5 October 2018

1 reference

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Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Tumor necrosis factor gene-engineered J558 tumor cell-released exosomes stimulate tumor antigen P1A-specific CD8+ CTL responses and antitumor immunity

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients.

5 October 2018

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A brilliant disguise for self RNA: 5'-end and internal modifications of primary transcripts suppress elements of innate immunity

5 October 2018

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Reactive oxygen species play a central role in the activity of cationic liposome based cancer vaccine

5 October 2018

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Results of the first phase I/II clinical vaccination trial with direct injection of mRNA.

5 October 2018

1 reference

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5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops

5 October 2018

1 reference

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5'-Triphosphate RNA is the ligand for RIG-I

5 October 2018

1 reference

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Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy

5 October 2018

1 reference

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Exploiting dendritic cells for cancer immunotherapy: genetic modification of dendritic cells

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Calcium signaling through phospholipase C activates dendritic cells to mature and is necessary for the activation and maturation of dendritic cells induced by diverse agonists.

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

B7-H1 pathway and its role in the evasion of tumor immunity.

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies

5 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5835019

Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers

5 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2017.11.009

Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29249397

12 December 2020

inferred from PubMed ID database lookup

Calcium mobilization in human myeloid cells results in acquisition of individual dendritic cell-like characteristics through discrete signaling pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29249397

12 December 2020

inferred from PubMed ID database lookup

Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29249397

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.YMTHE.2017.11.009

1 reference

22 February 2018

PMC publication ID

5835019

0 references

1 reference

22 February 2018