(Q50021891)

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A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death

scientific article published on 14 December 2016

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Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death (English)

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Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

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Akhouri Kishore Raghawan

1

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

Anand Sripada

2

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

Gayathri Gopinath

3

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

Pendyala Pushpanjali

4

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

Yatender Kumar

5

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

Vegesna Radha

6

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

Ghanshyam Swarup

7

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Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

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publication date

14 December 2016

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Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

292

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Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

4

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

1218-1230

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5270468/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Structural and biochemical basis for induced self-propagation of NLRC4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

An inherited mutation in NLRC4 causes autoinflammation in human and mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

The 26S proteasome and initiation of gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Crystal structure of NLRC4 reveals its autoinhibition mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Phosphorylation of NLRC4 is critical for inflammasome activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Biochemical regulation of the inflammasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Differential requirements for NAIP5 in activation of the NLRC4 inflammasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

FADD: a regulator of life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Induction of cytochrome c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

SUG1, a component of the 26 S proteasome, is an ATPase stimulated by specific RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

22 May 2018

Differential expression of inflammasomes in lung cancer cell lines and tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

14 August 2018

Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

14 August 2018

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

14 August 2018

The CULt of caspase-8 ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

14 August 2018

The active caspase-8 heterotetramer is formed at the CD95 DISC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5270468

29 September 2018

The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/27974463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of FADD and its mode of interaction with procaspase-8

1 reference

https://pubmed.ncbi.nlm.nih.gov/27974463

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.763979

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 February 2018

http://europepmc.org/abstract/PMC/5270468

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