(Q50027691)

23 February 2018

title

Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains. (English)

1 reference

23 February 2018

main subject

transmembrane protein

0 references

author name string

Leah Alabanza

1

1 reference

23 February 2018

Melissa Pegues

2

1 reference

23 February 2018

Claudia Geldres

3

1 reference

23 February 2018

Victoria Shi

4

1 reference

23 February 2018

Jed J W Wiltzius

5

1 reference

23 February 2018

Stuart A Sievers

6

1 reference

23 February 2018

Shicheng Yang

7

1 reference

23 February 2018

James N Kochenderfer

8

1 reference

23 February 2018

publication date

27 July 2017

1 reference

23 February 2018

published in

Molecular Therapy

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23 February 2018

volume

25

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23 February 2018

issue

11

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23 February 2018

page(s)

2452-2465

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23 February 2018

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels.

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T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

26 August 2018

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CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

26 August 2018

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GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade

26 August 2018

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Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease

26 August 2018

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Chimeric antigen receptor-redirected T cells return to the bench

26 August 2018

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26 August 2018

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Molecular and cellular insights into T cell exhaustion

26 August 2018

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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

26 August 2018

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Designing chimeric antigen receptors to effectively and safely target tumors

26 August 2018

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Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD.

26 August 2018

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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

26 August 2018

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Chimeric antigen receptor T cells for sustained remissions in leukemia

26 August 2018

1 reference

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The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

26 August 2018

1 reference

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Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor

26 August 2018

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Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia

26 August 2018

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Design and development of therapies using chimeric antigen receptor-expressing T cells

26 August 2018

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Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

The basic principles of chimeric antigen receptor design

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors.

26 August 2018

1 reference

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CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

26 August 2018

1 reference

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B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma

26 August 2018

1 reference

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

26 August 2018

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Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

26 August 2018

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26 August 2018

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Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

26 August 2018

1 reference

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CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

26 August 2018

1 reference

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Mechanisms for T cell receptor triggering

26 August 2018

1 reference

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Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice

26 August 2018

1 reference

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Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Concepts of activated T cell death

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Crystal structure of a soluble CD28-Fab complex

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo

26 August 2018

1 reference

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Activation-induced cell death in T cells

26 August 2018

1 reference

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Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity.

26 August 2018

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26 August 2018

The Protein Data Bank

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5675490

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors

26 August 2018

1 reference

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An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability.

26 August 2018

1 reference

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Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution

26 August 2018

1 reference

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Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

26 August 2018

1 reference

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The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens

29 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2017.07.013

10.1016/J.YMTHE.2017.07.013

7 January 2021

Identifiers

DOI

1 reference

23 February 2018

PMC publication ID

5675490

0 references

1 reference

23 February 2018