(Q50037939)

18 May 2018

title

Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers. (English)

1 reference

18 May 2018

author

Nicholas P. Restifo

6

1 reference

18 May 2018

author name string

Qiong J Wang

1

1 reference

18 May 2018

Zhiya Yu

2

1 reference

18 May 2018

Ken-Ichi Hanada

3

1 reference

18 May 2018

Krishna Patel

4

1 reference

18 May 2018

David Kleiner

5

1 reference

18 May 2018

James C Yang

7

1 reference

18 May 2018

language of work or name

English

0 references

publication date

1 November 2016

1 reference

18 May 2018

published in

Clinical Cancer Research

1 reference

18 May 2018

volume

23

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18 May 2018

issue

9

1 reference

18 May 2018

page(s)

2267-2276

1 reference

18 May 2018

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

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Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

22 May 2018

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CD70: An emerging target in cancer immunotherapy

22 May 2018

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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

22 May 2018

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22 May 2018

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A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response

22 May 2018

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Chimeric antigen receptor T cells for sustained remissions in leukemia

22 May 2018

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Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma

22 May 2018

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Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia

22 May 2018

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22 May 2018

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22 May 2018

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Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma

22 May 2018

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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

22 May 2018

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In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)

22 May 2018

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CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

22 May 2018

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Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

22 May 2018

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T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies

22 May 2018

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Development of a genetically-modified novel T-cell receptor for adoptive cell transfer against renal cell carcinoma.

22 May 2018

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T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

22 May 2018

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Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice

22 May 2018

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Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

22 May 2018

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Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication

22 May 2018

1 reference

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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

22 May 2018

1 reference

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Identification of CD70 as a diagnostic biomarker for clear cell renal cell carcinoma by gene expression profiling, real-time RT-PCR and immunohistochemistry

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

CD27 is required for generation and long-term maintenance of T cell immunity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

CD70 represents the human ligand for CD27.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

pVHL/HIF-regulated CD70 expression is associated with infiltration of CD27+ lymphocytes and increased serum levels of soluble CD27 in clear cell renal cell carcinoma.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

Expression of the murine CD27 ligand CD70 in vitro and in vivo.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5411349

Preclinical characterization of SGN-70, a humanized antibody directed against CD70

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27803044

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-16-1421

1 reference

18 May 2018

PMC publication ID

5411349

1 reference

18 May 2018

PubMed publication ID

27803044

1 reference

18 May 2018