(Q50071404)

English

Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment.

scientific article published on 4 June 2007

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scholarly article

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment. (English)

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

1 reference

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inferred from title

Albert J Fornace

5

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

author name string

Warren W Ku

1

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

Jiri Aubrecht

2

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

Robert J Mauthe

3

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

Robert H Schiestl

4

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

publication date

4 June 2007

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

Toxicological Sciences

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

99

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

1

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Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

20-25

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Stress-specific signatures: expression profiling of p53 wild-type and -null human cells

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Gene expression profile analysis: an emerging approach to investigate mechanisms of genotoxicity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Carcinogens induce intrachromosomal recombination in human cells

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Role of homologous recombination in carcinogenesis.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Aniline and its metabolites generate free radicals in yeast.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Diaminotoluenes induce intrachromosomal recombination and free radicals in Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Free radicals generated in yeast by the Salmonella test-negative carcinogens benzene, urethane, thiourea and auramine O.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Positive responses to carcinogens in the yeast DEL recombination assay are not due to selection of preexisting spontaneous revertants

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

The aromatic amine carcinogens o-toluidine and o-anisidine induce free radicals and intrachromosomal recombination in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Evaluation of the yeast DEL assay with 10 compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Alternative models for carcinogenicity testing

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Characteristic Expression Profiles Induced by Genotoxic Carcinogens in Rat Liver

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Salmonella test positive and negative carcinogens show different effects on intrachromosomal recombination in G2 cell cycle arrested yeast cells.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Development of a microtiter plate version of the yeast DEL assay amenable to high-throughput toxicity screening of chemical libraries

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Simultaneous measurement of the frequencies of intrachromosomal recombination and chromosome gain using the yeast DEL assay

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Use of genotoxicity data to support clinical trials or positive genetox findings on a candidate pharmaceutical or impurity .... now what?

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Global response of Saccharomyces cerevisiae to an alkylating agent

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Yeast DEL assay detects clastogens

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Carcinogenic Cr(VI) and the nutritional supplement Cr(III) induce DNA deletions in yeast and mice.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Microarrays and toxicology: the advent of toxicogenomics

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Interfaces between the detection, signaling, and repair of DNA damage

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Nonmutagenic carcinogens induce intrachromosomal recombination in yeast

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Carcinogens induce reversion of the mouse pink-eyed unstable mutation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Carcinogens induce intrachromosomal recombination in yeast.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

A review of the genotoxicity of marketed pharmaceuticals

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Neural computing in cancer drug development: predicting mechanism of action

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM147

21 January 2018

Identifiers

10.1093/TOXSCI/KFM147

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

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1 reference

https://api.fatcat.wiki/v0/release/36dabpxq65d3limkpc6o744to4

24 November 2022

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1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/17548889

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