(Q5009806)

English

inducible T cell costimulator

mammalian protein found in Homo sapiens

inducible costimulator
activation-inducible lymphocyte immunomediatory molecule
inducible T-cell costimulator
inducible T-cell co-stimulator
ICOS
Inducible T-Cell Co-Stimulator Protein

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Statements

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

13 November 2019

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6W8&geneProductId=UniProtKB:Q9Y6W8

4 references

9 May 2019

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

9 May 2019

ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

9 May 2019

Ligand binding sites of inducible costimulator and high avidity mutants with improved function

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

9 May 2019

Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

IPI

cell component

integral component of membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

IEA

integral component of plasma membrane

1 reference

9 May 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

IEA

external side of plasma membrane

1 reference

9 May 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

IEA

biological process

T cell tolerance induction

1 reference

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

1 reference

9 May 2019

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

NAS

phosphatidylinositol phosphate biosynthetic process

1 reference

7 November 2018

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6W8&geneProductId=UniProtKB:Q9Y6W8

1 reference

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

IEA

positive regulation of protein kinase B signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

9 May 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method

IBA

Gene Atlas image

PBB GE ICOS 210439 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q9Y6W8

1 reference

stated in

Identifiers.org

Identifiers

MeSH descriptor ID

D060889

subject named as

Inducible T-Cell Co-Stimulator Protein

0 references

MeSH tree code

D12.776.543.750.705.222.812

0 references

D23.050.301.264.894.580

0 references

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

(Q5009806)

inducible T cell costimulator

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