(Q50122438)

25 February 2018

title

Novel allosteric effectors of the tryptophan synthase alpha(2)beta(2) complex identified by computer-assisted molecular modeling. (English)

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25 February 2018

author

Anna Marabotti

series ordinal

1

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25 February 2018

Andrea Mozzarelli

series ordinal

3

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25 February 2018

author name string

P Cozzini

series ordinal

2

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25 February 2018

publication date

1 February 2000

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25 February 2018

Biochimica et Biophysica Acta

published in

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25 February 2018

volume

1476

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25 February 2018

issue

2

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25 February 2018

page(s)

287-299

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25 February 2018

Reciprocal communication between the lyase and synthase active sites of the tryptophan synthase bienzyme complex.

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7 January 2021

Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alphaD60N) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alphaGlu49

1 reference

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7 January 2021

Allosteric effects acting over a distance of 20-25 A in the Escherichia coli tryptophan synthase bienzyme complex increase ligand affinity and cause redistribution of covalent intermediates

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7 January 2021

Allosteric interactions coordinate catalytic activity between successive metabolic enzymes in the tryptophan synthase bienzyme complex

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7 January 2021

The tryptophan synthase bienzyme complex transfers indole between the alpha- and beta-sites via a 25-30 A long tunnel

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7 January 2021

Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes

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7 January 2021

Conformational changes and subunit communication in tryptophan synthase: effect of substrates and substrate analogs

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7 January 2021

Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates.

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7 January 2021

Characterization of the functional role of a flexible loop in the alpha-subunit of tryptophan synthase from Salmonella typhimurium by rapid-scanning, stopped-flow spectroscopy and site-directed mutagenesis

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7 January 2021

beta-Site covalent reactions trigger transitions between open and closed conformations of the tryptophan synthase bienzyme complex

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7 January 2021

Time-resolved fluorescence of tryptophan synthase.

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7 January 2021

Loop closure and intersubunit communication in tryptophan synthase

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7 January 2021

Affinities of phosphorylated substrates for the E. coli tryptophan synthase alpha-subunit: roles of Ser-235 and helix-8' dipole.

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Structural conservation in parallel beta/alpha-barrel enzymes that catalyze three sequential reactions in the pathway of tryptophan biosynthesis

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PCR mutagenesis and overexpression of tryptophan synthase from Salmonella typhimurium: on the roles of beta2 subunit Lys-382.

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Tryptophan synthase from Escherichia coli and Salmonella typhimurium.

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7 January 2021

Steady-state kinetic studies of the synthesis of indoleglycerol phosphate catalyzed by the alpha subunit of tryptophan synthase from Escherichia coli. Comparison with the alpha2 beta2-complex

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7 January 2021

An active proteolytic derivative of the .alpha. subunit of tryptophan synthase. Identification of the site of cleavage and characterization of the fragments

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Validation of the general purpose Tripos 5.2 force field

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7 January 2021

The Tryptophan Synthase from Escherichia coli. An Improved Purification Procedure for the alpha-Subunit and Binding Studies with Substrate Analogues

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7 January 2021

Monovalent cations affect dynamic and functional properties of the tryptophan synthase alpha 2 beta 2 complex.

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Fluorescence studies of substrate and subunit interactions of the .beta.2 protein of Escherichia coli tryptophan synthetase

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7 January 2021

Plasticity of the Tryptophan Synthase Active Site Probed by31P NMR Spectroscopy

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7 January 2021

Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60

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7 January 2021

Cooperative fluctuations and subunit communication in tryptophan synthase

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7 January 2021

Allosteric linkages between beta-site covalent transformations and alpha-site activation and deactivation in the tryptophan synthase bienzyme complex

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7 January 2021

Tryptophan-Requiring Mutants of the Plant Arabidopsis thaliana.

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Analysis of a chemical plant defense mechanism in grasses

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Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase

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7 January 2021

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Identifiers

DOI

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25 February 2018

release_nazjvb7btjee5mt2ezhhecdqn4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nazjvb7btjee5mt2ezhhecdqn4

24 November 2022

mapped directly with Wikidata item

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25 February 2018