(Q50123872)

25 February 2018

title

Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands. (English)

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25 February 2018

author name string

Ro HS

series ordinal

1

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25 February 2018

Wilson Miles E

series ordinal

2

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25 February 2018

language of work or name

English

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publication date

1 October 1999

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25 February 2018

Journal of Biological Chemistry

number of pages

6

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based on heuristic

inferred from page(s)

published in

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25 February 2018

volume

274

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25 February 2018

issue

44

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25 February 2018

page(s)

31189-31194

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25 February 2018

Protein architecture, dynamics and allostery in tryptophan synthase channeling

cites work

1 reference

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Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes

21 January 2018

1 reference

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Loop closure and intersubunit communication in tryptophan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.44.31189

Evidence of a low-barrier hydrogen bond in the tryptophan synthase catalytic mechanism

21 January 2018

1 reference

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The Intrinsic PkA-Values of Functional Groups in Enzymes: Improper Deductions from the Ph-Dependence of Steady-State Parameter

21 January 2018

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21 January 2018

Effects of pH on enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.44.31189

Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates.

21 January 2018

1 reference

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PCR mutagenesis and overexpression of tryptophan synthase from Salmonella typhimurium: on the roles of beta2 subunit Lys-382.

21 January 2018

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Tryptophan synthase from Escherichia coli and Salmonella typhimurium.

21 January 2018

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Detection and identification of intermediates in the reaction of L-serine with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

21 January 2018

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Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase.

21 January 2018

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On the mechanism of action of Escherichia coli tryptophan synthase Steady-state investigations

21 January 2018

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Kinetic studies of tryptophan synthetase. Interaction of L-serine, indole, and tryptophan with the native enzyme

21 January 2018

1 reference

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Monovalent cations affect dynamic and functional properties of the tryptophan synthase alpha 2 beta 2 complex.

21 January 2018

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Characterization of the reaction of L-serine and indole with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

21 January 2018

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Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants.

21 January 2018

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Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.

21 January 2018

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Mechanistic deductions from multiple kinetic and solvent deuterium isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Escherichia coli tryptophan indole-lyase

21 January 2018

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Mechanistic deductions from kinetic isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Erwinia herbicola and Citrobacter freundii tyrosine phenol-lyase.

21 January 2018

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Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60

21 January 2018

1 reference

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Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alphaD60N) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alphaGlu49

21 January 2018

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Mechanisms of monovalent cation action in enzyme catalysis: the first stage of the tryptophan synthase beta-reaction

21 January 2018

1 reference

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Importance of conserved and variable C-terminal residues for the activity and thermal stability of the beta subunit of tryptophan synthase

21 January 2018

1 reference

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Exchange of K+ or Cs+ for Na+ induces local and long-range changes in the three-dimensional structure of the tryptophan synthase alpha2beta2 complex

21 January 2018

1 reference

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Oxidation of tryptophan to oxindolylalanine by dimethyl sulfoxide-hydrochloric acid. Selective modification of tryptophan containing peptides

21 January 2018

1 reference

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Interactions of tryptophan synthase, tryptophanase, and pyridoxal phosphate with oxindolyl-L-alanine and 2,3-dihydro-L-tryptophan: support for an indolenine intermediate in tryptophan metabolism

21 January 2018

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Hydrogen exchange kinetics and the mechanism of reaction B of yeast tryptophan synthase

21 January 2018

1 reference

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Monovalent cations partially repair a conformational defect in a mutant tryptophan synthase alpha 2 beta 2 complex (beta-E109A)

21 January 2018

1 reference

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Mechanism of activation of the tryptophan synthase alpha2beta2 complex. Solvent effects of the co-substrate beta-mercaptoethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.44.31189

Guanidine hydrochloride exerts dual effects on the tryptophan synthase alpha 2 beta 2 complex as a cation activator and as a modulator of the active site conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.44.31189

Mutations in the contact region between the alpha and beta subunits of tryptophan synthase alter subunit interaction and intersubunit communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.44.31189

21 January 2018

Identifiers

DOI

10.1074/JBC.274.44.31189

1 reference

25 February 2018

PubMed ID

10531312

1 reference

25 February 2018