(Q50285967)

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Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-8942607)

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8 July 2022

Cyclin D associated events in G1

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-8942607

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8 July 2022

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8 July 2022

CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol]

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8 July 2022

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8 July 2022

CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C) [cytosol]

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8 July 2022

(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol]

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8 July 2022

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

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8 July 2022

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"

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8 July 2022

Switching cyclin D-Cdk4 kinase activity on and off.

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8 July 2022

Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity

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8 July 2022

p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells.

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8 July 2022

Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4

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8 July 2022

Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4

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8 July 2022

Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase.

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8 July 2022

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

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8 July 2022

Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

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8 July 2022

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

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8 July 2022

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

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8 July 2022

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control

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8 July 2022

Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein

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8 July 2022

Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.

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8 July 2022

The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis.

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8 July 2022

Identifiers

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8 July 2022

(Q50285967)

Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes

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