(Q28115769)

3 January 2017

title

Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4 (English)

1 reference

Protein tyrosine kinase 6

3 January 2017

0 references

1 reference

protein tyrosine kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Priyank Patel

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Angela L. Tyner

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Benedikt Asbach

2

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Elina Shteyn

3

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Cindy Gomez

4

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Alexander Coltoff

5

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Sadia Bhuyan

6

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Ralf Wagner

8

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Stacy W Blain

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

English

0 references

publication date

1 May 2015

1 reference

Molecular and Cellular Biology

3 January 2017

published in

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

35

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

issue

9

2 references

3 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

1506-1522

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome

4 June 2020

cites work

1 reference

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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

20 March 2017

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Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

20 March 2017

1 reference

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Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

20 March 2017

1 reference

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

20 March 2017

1 reference

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Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control

20 March 2017

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Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

20 March 2017

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20 March 2017

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

20 March 2017

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CDK inhibitors: positive and negative regulators of G1-phase progression

20 March 2017

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Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

20 March 2017

1 reference

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Role of the Brk SH3 domain in substrate recognition

20 March 2017

1 reference

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Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells

20 March 2017

1 reference

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Brk, Srm, Frk, and Src42A Form a Distinct Family of Intracellular Src-Like Tyrosine Kinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

20 March 2017

1 reference

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Requirement for CDK4 kinase function in breast cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Palbociclib: an evidence-based review of its potential in the treatment of breast cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Molecular pathways: CDK4 inhibitors for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Regulation of p27 (Kip1) by mitogen-induced tyrosine phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Targeting p27Kip1 protein: its relevance in the therapy of human cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Deregulation of the cell cycle by breast tumor kinase (Brk).

29 September 2017

1 reference

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Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Switching cyclin D-Cdk4 kinase activity on and off.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Interaction between Brk kinase and insulin receptor substrate-4.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Variation on an Src-like theme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

p27 as a target for cancer therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Cyclin D-dependent kinases, INK4 inhibitors and cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Can we infer peptide recognition specificity mediated by SH3 domains?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Specific protection against breast cancers by cyclin D1 ablation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Vertebrate non-receptor protein-tyrosine kinase families

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Tyrosine kinase gene expression in the mouse small intestine.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone marrow myeloma cells.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

DNA vaccination against mutant huntingtin ameliorates the HDR6/2 diabetic phenotype.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4387217

Is Cyclin D1-CDK4 kinase a bona fide cancer target?

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25733683

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

BRK tyrosine kinase expression in a high proportion of human breast carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/25733683

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.01206-14

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25733683%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

2 references