(Q33912469)

30 July 2017

1 reference

title

Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK (English)

1 reference

30 July 2017

Angela L Tyner

2

0 references

author name string

Patrick M Brauer

series ordinal

1

1 reference

30 July 2017

language of work or name

English

0 references

publication date

26 February 2010

1 reference

Biochimica et Biophysica Acta

30 July 2017

published in

1 reference

30 July 2017

volume

1806

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30 July 2017

issue

1

1 reference

30 July 2017

page(s)

66-73

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Osteopontin: an effector and an effect of tumor metastasis.

30 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest

5 July 2018

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5 July 2018

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STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

5 July 2018

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5 July 2018

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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

5 July 2018

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Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus

5 July 2018

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Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck

5 July 2018

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Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

5 July 2018

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Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.

5 July 2018

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The Stat family of transcription factors have diverse roles in mammary gland development

5 July 2018

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Brk is coamplified with ErbB2 to promote proliferation in breast cancer

5 July 2018

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New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation

5 July 2018

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The function of Stat3 in tumor cells and their microenvironment

5 July 2018

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Her2 cross talk and therapeutic resistance in breast cancer

5 July 2018

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The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation

5 July 2018

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Predicting the efficacy of trastuzumab-based therapy in breast cancer: current standards and future strategies

5 July 2018

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Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

5 July 2018

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Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitro

5 July 2018

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Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms

5 July 2018

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

5 July 2018

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Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines

5 July 2018

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Solid-phase peptide library synthesis on HiCore resin for screening substrate specificity of Brk protein tyrosine kinase

5 July 2018

1 reference

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Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6

5 July 2018

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5 July 2018

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Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6.

5 July 2018

1 reference

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Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis

5 July 2018

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5 July 2018

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Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

5 July 2018

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PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas.

5 July 2018

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Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).

5 July 2018

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Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation

5 July 2018

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The BRK tyrosine kinase is expressed in high-grade serous carcinoma of the ovary

5 July 2018

1 reference

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Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine

5 July 2018

1 reference

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Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

5 July 2018

1 reference

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Identification of STAT3 as a specific substrate of breast tumor kinase

5 July 2018

1 reference

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Critical nodes in signalling pathways: insights into insulin action

5 July 2018

1 reference

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Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

5 July 2018

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Estradiol regulates different genes in human breast tumor xenografts compared with the identical cells in culture

5 July 2018

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Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

5 July 2018

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Role of breast tumour kinase in the in vitro differentiation of HaCaT cells.

5 July 2018

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The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis

5 July 2018

1 reference

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An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.

5 July 2018

1 reference

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Interaction between Brk kinase and insulin receptor substrate-4.

5 July 2018

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Simultaneous over-expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas

5 July 2018

1 reference

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Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

5 July 2018

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Regulated association of protein kinase B/Akt with breast tumor kinase

5 July 2018

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Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium.

5 July 2018

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The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

5 July 2018

1 reference

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The Brk protein tyrosine kinase as a therapeutic target in cancer: opportunities and challenges

5 July 2018

1 reference

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Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain

5 July 2018

1 reference

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Identification of tyrosine kinases overexpressed in head and neck cancer

5 July 2018

1 reference

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Role of the Brk SH3 domain in substrate recognition

5 July 2018

1 reference

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Non-Small-Cell Lung Cancer Molecular Signatures Recapitulate Lung Developmental Pathways

5 July 2018

1 reference

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Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Brk, Srm, Frk, and Src42A Form a Distinct Family of Intracellular Src-Like Tyrosine Kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition

5 July 2018

1 reference

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Characterization of the 5'-flanking region of the human PTK6 gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

5 July 2018

1 reference

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Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

5 July 2018

1 reference

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Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling

5 July 2018

1 reference

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A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

BRK/Sik expression in the gastrointestinal tract and in colon tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Isolation of a cDNA encoding a tyrosine kinase expressed in murine skin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Vertebrate non-receptor protein-tyrosine kinase families

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Nucleocytoplasmic transport: signals, mechanisms and regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Tyrosine kinase gene expression in the mouse small intestine.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Overexpression of PTK6 (breast tumor kinase) protein--a prognostic factor for long-term breast cancer survival--is not due to gene amplification.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Gene expansion and retention leads to a diverse tyrosine kinase superfamily in amphioxus

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

ADAM15 upregulation and interaction with multiple binding partners in inflammatory bowel disease.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Effects of embryo culture on global pattern of gene expression in preimplantation mouse embryos.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Expression profile of tyrosine kinases in breast cancer.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885473

Calcium signals in prostate cancer cells: specific activation by bone-matrix proteins

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20193745

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

BRK tyrosine kinase expression in a high proportion of human breast carcinomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20193745

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20193745

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BBCAN.2010.02.003

1 reference

30 July 2017

1 reference

30 July 2017

1 reference