(Q37703338)

22 August 2017

1 reference

title

Osteopontin: an effector and an effect of tumor metastasis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

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L A Shevde

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

S Das

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

D W Clark

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

R S Samant

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

publication date

1 February 2010

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Current Molecular Medicine

22 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

volume

10

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13 May 2020

issue

1

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13 May 2020

page(s)

71-81

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells

13 May 2020

cites work

1 reference

12 December 2020

A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5

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12 December 2020

Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer.

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12 December 2020

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12 December 2020

Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways

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12 December 2020

CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis

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12 December 2020

Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells

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12 December 2020

The carboxyl-terminal fragment of osteopontin suppresses arginine-glycine-asparatic acid-dependent cell adhesion

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12 December 2020

Caprine uterine and placental osteopontin expression is distinct among epitheliochorial implanting species

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12 December 2020

How matrix metalloproteinases regulate cell behavior

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12 December 2020

The Role of osteopontin in lung disease

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12 December 2020

Structural characterization and comparison of RGD cell-adhesion recognition sites engineered into streptavidin

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12 December 2020

Systemic endocrine instigation of indolent tumor growth requires osteopontin

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12 December 2020

Impaired anti-tumor cytotoxicity of macrophages from osteopontin-deficient mice

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12 December 2020

Osteopontin expression in primary sarcomas of the pulmonary artery

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12 December 2020

Urokinase plasminogen activator system gene expression is increased in human breast carcinoma and its bone metastases--a comparison of normal breast tissue, non-invasive and invasive carcinoma and osseous metastases

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12 December 2020

Tissue factor, osteopontin, alphavbeta3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression

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12 December 2020

Muc-1, integrin, and osteopontin expression during the implantation cascade in sheep

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12 December 2020

Role of osteopontin in amplification and perpetuation of rheumatoid synovitis

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12 December 2020

Osteopontin modulates CD44‐dependent chemotaxis of peritoneal macrophages through G‐protein‐coupled receptors: Evidence of a role for an intracellular form of osteopontin

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12 December 2020

Plasma osteopontin levels are predictive of disease stage in patients with transitional cell carcinoma of the bladder

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12 December 2020

Osteopontin: it's role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression

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12 December 2020

Osteopontin stimulates vascular smooth muscle cell migration by inducing FAK phosphorylation and ILK dephosphorylation

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12 December 2020

Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells

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12 December 2020

Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro)

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12 December 2020

An in vivo model of prostate carcinoma growth and invasion in bone

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12 December 2020

TPA-mediated regulation of osteopontin in human malignant glioma cells.

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12 December 2020

Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration

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12 December 2020

Characterization of the interaction between integrins and recombinant human osteopontin

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12 December 2020

Osteopontin overexpression in breast cancer: knowledge gained and possible implications for clinical management.

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12 December 2020

Molecular role(s) for integrins in human melanoma invasion

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12 December 2020

Utility of Osteopontin and Serum Mesothelin in Malignant Pleural Mesothelioma Diagnosis and Prognosis Assessment

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12 December 2020

The role of alpha(v)beta(3) in prostate cancer progression

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12 December 2020

Osteopontin is a ligand for the alpha4beta1 integrin

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12 December 2020

RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer

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12 December 2020

Expression of osteopontin and HGF/met in adult soft tissue tumors

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12 December 2020

Angiogenesis and metastasis

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12 December 2020

Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer

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12 December 2020

The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model

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12 December 2020

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

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12 December 2020

A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis

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12 December 2020

Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts

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12 December 2020

Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter

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12 December 2020

Lower osteopontin plasma levels are associated with superior outcomes in advanced non-small-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003

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12 December 2020

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12 December 2020

Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo

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12 December 2020

Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway

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12 December 2020

Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival

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12 December 2020

Substrate specificity of alpha(v)beta(3) integrin-mediated cell migration and phosphatidylinositol 3-kinase/AKT pathway activation

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12 December 2020

Osteopontin involvement in integrin-mediated cell signaling and regulation of expression of alkaline phosphatase during early differentiation of UMR cells

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12 December 2020

Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling

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12 December 2020

Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer

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12 December 2020

Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways

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12 December 2020

The biology of renal cancer metastasis

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12 December 2020

Osteopontin-c is a selective marker of breast cancer

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12 December 2020

Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer.

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12 December 2020

The relationship between bone metastasis from human breast cancer and integrin alpha(v)beta3 expression.

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12 December 2020

Normal rat kidney cells secrete both phosphorylated and nonphosphorylated forms of osteopontin showing different physiological properties

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12 December 2020

Expression of osteopontin mRNA and its protein in colorectal cancer and liver metastatic tissues

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12 December 2020

Renal osteopontin expression in experimental urolithiasis.

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12 December 2020

Role of osteopontin in cellular signaling and metastatic phenotype

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12 December 2020

A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis

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12 December 2020

Expression of bone sialoprotein and osteopontin in breast cancer bone metastases

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12 December 2020

Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha

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12 December 2020

Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy

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12 December 2020

Critical determinants of metastasis

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12 December 2020

Expression of Antisense Osteopontin RNA in Metastatic Mouse Fibroblasts Is Associated with Reduced Malignancy

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12 December 2020

Osteopontin: an intrinsic inhibitor of inflammation in cartilage

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12 December 2020

Integrin alpha V beta 3 expression by bone-residing breast cancer metastases

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12 December 2020

Secreted phosphoprotein mRNA is induced during multi-stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts

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12 December 2020

The mutagenesis of the RGD sequence of recombinant osteopontin causes it to lose its cell adhesion ability

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12 December 2020

Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation.

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12 December 2020

Osteopontin stimulates melanoma growth and lung metastasis through NIK/MEKK1-dependent MMP-9 activation pathways.

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12 December 2020

Control of osteopontin signaling and function by post-translational phosphorylation and protein folding

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12 December 2020

A small interfering RNA targeting osteopontin as gastric cancer therapeutics

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12 December 2020

Osteopontin expression in lung cancer

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12 December 2020

The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms

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12 December 2020

Plasma osteopontin, hypoxia, and response to radiotherapy in nasopharyngeal cancer.

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12 December 2020

Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain

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12 December 2020

MDA-MB-435 cells are from melanoma, not from breast cancer

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12 December 2020

Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumors

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12 December 2020

Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells

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12 December 2020

CD44 engagement promotes matrix-derived survival through the CD44-SRC-integrin axis in lipid rafts

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12 December 2020

Serial Plasma Osteopontin Levels Have Prognostic Value in Metastatic Breast Cancer

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12 December 2020

Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas

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12 December 2020

Osteopontin(OPN)-induced increase in human mammary epithelial cell invasiveness is urokinase (uPA)-dependent

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12 December 2020

Osteopontin expression and adventitial angiogenesis induced by local vascular endothelial growth factor 165 reduces experimental aortic calcification

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12 December 2020

Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies.

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12 December 2020

Angiogenesis and cancer metastasis.

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12 December 2020

Further evidence to support the melanocytic origin of MDA-MB-435

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12 December 2020

Response of the plasma hypoxia marker osteopontin to in vitro hypoxia in human tumor cells

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12 December 2020

Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor

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12 December 2020

Osteopontin and colon cancer progression

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12 December 2020

Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression

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12 December 2020

Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties

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12 December 2020

Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues

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12 December 2020

Osteopontin expression correlates with melanoma invasion.

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12 December 2020

A decade's studies on metastasis of hepatocellular carcinoma

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12 December 2020

Osteopontin: possible role in prostate cancer progression

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12 December 2020

Receptor-ligand interaction between CD44 and osteopontin (Eta-1)

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12 December 2020

Antibodies to different peptides in osteopontin reveal complexities in the various secreted forms

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12 December 2020

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro

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12 December 2020

Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer

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12 December 2020

Different roles for plasminogen activators and metalloproteinases in melanoma metastasis.

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12 December 2020

Papilloma development is delayed in osteopontin-null mice: implicating an antiapoptosis role for osteopontin.

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12 December 2020

Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone

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12 December 2020

Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3

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12 December 2020

The role of osteopontin in breast cancer: clinical and experimental studies

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12 December 2020

Regulation of matrix biology by matrix metalloproteinases

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12 December 2020

The role of osteopontin in tumor progression and metastasis in breast cancer

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12 December 2020

Ultrastructural immunogold localization of osteopontin in human gastric mucosa

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12 December 2020

Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model

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12 December 2020

Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease

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12 December 2020

Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation

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12 December 2020

Osteopontin: regulation in tumor metastasis

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12 December 2020

Update on metastatic breast cancer

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12 December 2020

Thrombin Activatable Fibrinolysis Inhibitor, a Potential Regulator of Vascular Inflammation

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12 December 2020

Osteopontin and beta 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro

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12 December 2020

The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis

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12 December 2020

Osteopontin deficiency in rat vascular smooth muscle cells is associated with an inability to adhere to collagen and increased apoptosis

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12 December 2020

Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer.

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12 December 2020

The role of Osteopontin in tumor metastasis

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12 December 2020

Role of osteopontin in adhesion, migration, cell survival and bone remodeling

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12 December 2020

Expression of antisense osteopontin RNA inhibits tumor promoter-induced neoplastic transformation of mouse JB6 epidermal cells.

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12 December 2020

Osteopontin: a protein with diverse functions.

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12 December 2020

Identification of osteopontin (OPN) mRNA and protein in the rat testis and epididymis, and on sperm

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12 December 2020

An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo

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12 December 2020

Osteopontin as a potential diagnostic biomarker for ovarian cancer

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12 December 2020

Differentiation, maturation, and survival of dendritic cells by osteopontin regulation.

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12 December 2020

Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis

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12 December 2020

Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin

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12 December 2020

Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells

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12 December 2020

Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

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12 December 2020

Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors

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12 December 2020

Site-directed mutagenesis of the arginine-glycine-aspartic acid sequence in osteopontin destroys cell adhesion and migration functions

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12 December 2020

Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus

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12 December 2020

Osteopontin: a versatile regulator of inflammation and biomineralization

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12 December 2020

Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches

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12 December 2020

Blockade of integrin beta3-FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury

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12 December 2020

Vascular endothelial growth factor and osteopontin in tumor biology

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12 December 2020

Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis.

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12 December 2020

Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages

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12 December 2020

Down-regulation of osteopontin attenuates breast tumour progression in vivo

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12 December 2020

MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research

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12 December 2020

Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages.

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12 December 2020

Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation

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12 December 2020

Ras-responsive genes and tumor metastasis

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12 December 2020

Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)

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12 December 2020

A multigenic program mediating breast cancer metastasis to bone

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12 December 2020

Lentiviral-mediated miRNA against osteopontin suppresses tumor growth and metastasis of human hepatocellular carcinoma

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12 December 2020

Altered sialylation of osteopontin prevents its receptor-mediated binding on the surface of oncogenically transformed tsB77 cells

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12 December 2020

NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival

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12 December 2020

Osteopontin: role in immune regulation and stress responses

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12 December 2020

Osteopontin induces angiogenesis of murine neuroblastoma cells in mice

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12 December 2020

Osteopontin expression in a group of lymph node negative breast cancer patients

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12 December 2020

RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells

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12 December 2020

Tumor-derived osteopontin is soluble, not matrix associated

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12 December 2020

Differential effects of osteopontin on the cytotoxic activity of macrophages from young and old mice

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12 December 2020

Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts

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12 December 2020

Agelastatin A: a novel inhibitor of osteopontin-mediated adhesion, invasion, and colony formation

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12 December 2020

The functional and clinical roles of osteopontin in cancer and metastasis.

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12 December 2020

Prognostic significance of osteopontin expression in human gastric carcinoma

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12 December 2020

Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435

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12 December 2020

Induction of expression of osteopontin (OPN; secreted phosphoprotein) in metastatic, ras-transformed NIH 3T3 cells

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12 December 2020

Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells

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12 December 2020

Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line

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12 December 2020

Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms

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12 December 2020

Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites

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12 December 2020

Plasma osteopontin levels in patients with head and neck cancer and cervix cancer are critically dependent on the choice of ELISA system

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12 December 2020

Management of Bone Metastases in Advanced Breast Cancer

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12 December 2020

Vascular endothelial growth factor induces extracellular matrix proteins and osteopontin in the umbilical artery

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12 December 2020

Role of osteopontin in tumour progression

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12 December 2020

Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma

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12 December 2020

Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression

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12 December 2020

Osteopontin: role in cell signaling and cancer progression

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12 December 2020

An osteopontin splice variant induces anchorage independence in human breast cancer cells

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12 December 2020

Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC.

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12 December 2020

Metastatic potential of human neoplasms.

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12 December 2020

Synergy between a plasminogen cascade and MMP-9 in autoimmune disease

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12 December 2020

Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin

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12 December 2020

Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma.

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12 December 2020

Human marrow stromal cells activate monocytes to secrete osteopontin, which down-regulates Notch1 gene expression in CD34+ cells

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12 December 2020

Matrix-degrading proteases and angiogenesis during development and tumor formation.

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12 December 2020

Metastatic breast cancer: clinical course, prognosis and therapy related to the first site of metastasis

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12 December 2020

Osteopontin influences the invasiveness of pancreatic cancer cells and is increased in neoplastic and inflammatory conditions.

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12 December 2020

Obstructive uropathy in the mouse: role of osteopontin in interstitial fibrosis and apoptosis

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12 December 2020

Osteopontin expression and regulation in the testis, efferent ducts, and epididymis of rats during postnatal development through to adulthood

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12 December 2020

Analysis of osteopontin at the maternal-placental interface in pigs

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12 December 2020

Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis

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12 December 2020

Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro

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12 December 2020

Arterial microvascularization and breast cancer colonization in bone.

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12 December 2020

Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack

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12 December 2020

Increased expression of osteonectin and osteopontin, two bone matrix proteins, in human breast cancer.

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12 December 2020

10.2174/156652410791065381

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6869338&resulttype=core&format=json

13 May 2020

1 reference