(Q37847584)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

review article

1 reference

title

Targeting p27Kip1 protein: its relevance in the therapy of human cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1

1 reference

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23 January 2020

Silvio Naviglio

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Fulvio Della Ragione

11

1 reference

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23 January 2020

author name string

Debora Bencivenga

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Maria Criscuolo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Ilaria Caldarelli

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Valeria Cucciolla

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Annunziata Tramontano

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Alessia Borgia

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Annamaria Spina

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Adriana Oliva

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

language of work or name

English

0 references

publication date

28 February 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

23 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

page(s)

677-693

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

23 January 2020

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 January 2018

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A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

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Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

21 January 2018

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Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division

21 January 2018

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Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation

21 January 2018

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Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

21 January 2018

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p27Kip1 metabolism: a fascinating labyrinth

21 January 2018

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p27Kip1 modulates cell migration through the regulation of RhoA activation.

21 January 2018

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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

21 January 2018

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Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1

21 January 2018

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

21 January 2018

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14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)

21 January 2018

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 January 2018

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Transforming growth factor-beta and p27 expression in pituitary cells

21 January 2018

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p27Kip1 and cyclin dependent kinase 2 regulate passage through the restriction point

21 January 2018

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Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression

21 January 2018

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Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4

21 January 2018

1 reference

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

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Cdc2-cyclin E complexes regulate the G1/S phase transition

21 January 2018

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The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.

21 January 2018

1 reference

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p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex

21 January 2018

1 reference

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RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

21 January 2018

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Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity

21 January 2018

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Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma

21 January 2018

1 reference

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Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis.

21 January 2018

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Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration

21 January 2018

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Coordinate control of proliferation and migration by the p27Kip1/cyclin-dependent kinase/retinoblastoma pathway in vascular smooth muscle cells and fibroblasts.

21 January 2018

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Coupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis

21 January 2018

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p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis.

21 January 2018

1 reference

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p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling

21 January 2018

1 reference

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Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

21 January 2018

1 reference

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Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition

21 January 2018

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Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1)

21 January 2018

1 reference

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Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of HT29 human colon carcinoma cells

21 January 2018

1 reference

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Increased expression of p27 is associated with the cisplatin resistance in gastric cancer cell line YCC-3.

21 January 2018

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Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

21 January 2018

1 reference

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

1 reference

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miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.

21 January 2018

1 reference

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Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation

21 January 2018

1 reference

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MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle

21 January 2018

1 reference

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MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma

21 January 2018

1 reference

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MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1

21 January 2018

1 reference

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MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27.

21 January 2018

1 reference

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A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

The COP9 signalosome regulates Skp2 levels and proliferation of human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

MAP kinase-dependent degradation of p27Kip1 by calpains in choroidal melanoma cells. Requirement of p27Kip1 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Keeping p27(Kip1) in the cytoplasm: a second front in cancer's war on p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Regulation of p27Kip1 by miRNA 221/222 in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Expression profiling identifies microRNA signature in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Interaction of molecular markers and physical activity on mortality in patients with colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Expression of p21(waf1/cip1), p27 (kip1), p63 and androgen receptor in low and high Gleason score prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Biological correlates of p27 compartmental expression in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

SRC: A Century of Science Brought to the Clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27Kip1 signaling axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Histone deacetylases and cancer: causes and therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

p27Kip1 accumulation is associated with retinoic-induced neuroblastoma differentiation: evidence of a decreased proteasome-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Retinoic acid inhibits the growth of bone marrow mesenchymal stem cells and induces p27Kip1 and p16INK4A up-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Proteasome inhibitors in cancer therapy: lessons from the first decade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561318

10.1517/14728222.2011.561318

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21355788%20AND%20SRC:MED&resulttype=core&format=json

release_q4uko7qqizg3binqcdhgpaegyq

23 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/q4uko7qqizg3binqcdhgpaegyq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference