(Q34763495)

4 August 2017

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title

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy (English)

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4 August 2017

Isabel M Chu

1

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4 August 2017

Ludger Hengst

series ordinal

2

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4 August 2017

Joyce M Slingerland

series ordinal

3

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4 August 2017

language of work or name

English

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publication date

1 April 2008

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4 August 2017

Nature Reviews Cancer

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4 August 2017

8

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4 August 2017

253-267

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4 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrc2347

4 August 2017

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cites work

CDK inhibitors: positive and negative regulators of G1-phase progression

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Targets of cyclin-dependent protein kinases.

31 March 2020

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Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity

31 March 2020

1 reference

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

31 March 2020

1 reference

Translational control of p27Kip1 accumulation during the cell cycle

31 March 2020

1 reference

Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

31 March 2020

1 reference

Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?

31 March 2020

1 reference

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

1 reference

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

31 March 2020

1 reference

Identification of a tumour suppressor network opposing nuclear Akt function

31 March 2020

1 reference

Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity

31 March 2020

1 reference

Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression

31 March 2020

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Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

31 March 2020

1 reference

Analysis of p27(Kip1) expression in insulinomas developed in pancreatic beta-cell specific Men1 mutant mice.

31 March 2020

1 reference

Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans

31 March 2020

1 reference

Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers

31 March 2020

1 reference

Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

31 March 2020

1 reference

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

31 March 2020

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Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis

31 March 2020

1 reference

Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.

31 March 2020

1 reference

Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements

31 March 2020

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Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

31 March 2020

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Vitamin D3 receptor/Sp1 complex is required for the induction of p27Kip1 expression by vitamin D3.

31 March 2020

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Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells

31 March 2020

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Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.

31 March 2020

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Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF

31 March 2020

1 reference

Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation

31 March 2020

1 reference

ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

31 March 2020

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Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita

31 March 2020

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Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase

31 March 2020

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A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.

31 March 2020

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Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression

31 March 2020

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Role of the RNA-binding protein HuR in colon carcinogenesis

31 March 2020

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Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status.

31 March 2020

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Inhibition of Cdk4 activity enhances translation of p27kip1 in quiescent Rb-negative cells

31 March 2020

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Diverse ways to control p27Kip1 function: miRNAs come into play

31 March 2020

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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

31 March 2020

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miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.

31 March 2020

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A microRNA expression signature of human solid tumors defines cancer gene targets

31 March 2020

1 reference

MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle

31 March 2020

1 reference

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

31 March 2020

1 reference

Ubiquitin ligases: cell-cycle control and cancer

31 March 2020

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Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

31 March 2020

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Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

31 March 2020

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Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

31 March 2020

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

31 March 2020

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

31 March 2020

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A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

31 March 2020

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Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome

31 March 2020

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Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

31 March 2020

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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

31 March 2020

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The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase

31 March 2020

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

31 March 2020

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Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

31 March 2020

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

31 March 2020

1 reference

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

31 March 2020

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

31 March 2020

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C-terminal phosphorylation controls the stability and function of p27kip1

31 March 2020

1 reference

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

31 March 2020

1 reference

c-Src and cooperating partners in human cancer

31 March 2020

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HER-2/neu as a predictive marker of response to breast cancer therapy

31 March 2020

1 reference

Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results

31 March 2020

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Correlation of p27 protein expression with HER-2/neu expression in breast cancer.

31 March 2020

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Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

31 March 2020

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Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

31 March 2020

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P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.

31 March 2020

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Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

31 March 2020

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Clinical significance of cyclin-dependent kinase inhibitor p27Kip1 expression and proliferation in non-Hodgkin's lymphoma: independent prognostic value of p27Kip1

31 March 2020

1 reference

The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

31 March 2020

1 reference

BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells

31 March 2020

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BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

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Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma.

31 March 2020

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Role of the F-box protein Skp2 in lymphomagenesis

31 March 2020

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Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

31 March 2020

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The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma

31 March 2020

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

31 March 2020

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Skp2 and Jab1 expression are associated with inverse expression of p27(KIP1) and poor prognosis in oral squamous cell carcinomas

31 March 2020

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Skp2 is oncogenic and overexpressed in human cancers

31 March 2020

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A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

31 March 2020

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Skp2-mediated degradation of p27 regulates progression into mitosis.

31 March 2020

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

31 March 2020

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

31 March 2020

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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

31 March 2020

1 reference

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

31 March 2020

1 reference

New functional activities for the p21 family of CDK inhibitors

31 March 2020

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

31 March 2020

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

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Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry

31 March 2020

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14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)

31 March 2020

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

31 March 2020

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Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

31 March 2020

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Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

31 March 2020

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p21-containing cyclin kinases exist in both active and inactive states

31 March 2020

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Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

31 March 2020

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

31 March 2020

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Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

31 March 2020

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

31 March 2020

1 reference

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

31 March 2020

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Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization

31 March 2020

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Subcellular Localization and Protein Levels of Cyclin-Dependent Kinase Inhibitor p27 Independently Predict for Survival in Epithelial Ovarian Cancer

31 March 2020

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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

31 March 2020

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Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

31 March 2020

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Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity

31 March 2020

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Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma

31 March 2020

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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

31 March 2020

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p27/kip1 expression in normal epithelium, benign and neoplastic breast lesions

31 March 2020

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Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases

31 March 2020

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Expression of p21Waf1, p27Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ: Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status

31 March 2020

1 reference

Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation.

31 March 2020

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Loss of E-cadherin and p27 expression is associated with head and neck squamous tumorigenesis

31 March 2020

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Clinical relevance of expression of the CIP/KIP cell-cycle inhibitors p21 and p27 in laryngeal cancer

31 March 2020

1 reference

Prognostic value of cell cycle proteins p27(kip1) and MIB-1, and the cell adhesion protein CD44s in surgically treated patients with prostate cancer

31 March 2020

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Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma

31 March 2020

1 reference

Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors

31 March 2020

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The combined evaluation of p27Kip1 and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients

31 March 2020

1 reference

The cyclin-dependent kinase inhibitor p27 as a prognostic factor in advanced non-small cell lung cancer: its immunohistochemical evaluation using biopsy specimens

31 March 2020

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Reduced expression of cell-cycle regulator p27(Kip1) correlates with a shortened survival in non-small cell lung cancer

31 March 2020

1 reference

High cyclin E and low p27/Kip1 expressions are potentially poor prognostic factors in lung adenocarcinoma patients

31 March 2020

1 reference

Prognostic significance of p27KIP1 expression in resected non-small cell lung cancers: analysis in combination with expressions of p16INK4A, pRB, and p53

31 March 2020

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Relationship between postoperative recurrence and expression of cyclin E, p27, and Ki-67 in non-small cell lung cancer without lymph node metastases

31 March 2020

1 reference

Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

31 March 2020

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 March 2020

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Positive correlation between p27Kip1 expression and progression of human esophageal squamous cell carcinoma.

31 March 2020

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Expression of protein p27 is associated with progression and prognosis in laryngeal cancer

31 March 2020

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Prognostic value of p27(Kip1) and CyclinD1 expression in esophageal cancer

31 March 2020

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Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma

31 March 2020

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Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma

31 March 2020

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Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx

31 March 2020

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Loss of p27(KIP1) expression predicts poor prognosis in patients with esophageal squamous cell carcinoma

31 March 2020

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Significance of the expression of p27Kip1 in esophageal squamous cell carcinomas

31 March 2020

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Cyclin-dependent kinase inhibitor p27 is related to cell proliferation and prognosis in laryngeal squamous cell carcinomas

31 March 2020

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Prognostic role of p27(Kip1) expression in oral squamous cell carcinoma in Taiwan.

31 March 2020

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Prognostic significance of G1 cell-cycle inhibitors in early laryngeal cancer

31 March 2020

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Prognostic significance of expression patterns of c-erbB-2, p53, p16INK4A, p27KIP1, cyclin D1 and epidermal growth factor receptor in oesophageal adenocarcinoma: a tissue microarray study

31 March 2020

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

31 March 2020

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Absence of the cell cycle inhibitor p27Kip1 protein predicts poor outcome in patients with stage I-III colorectal cancer

31 March 2020

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Prognostic significance of p27(Kip1) expression in colorectal cancer: a clinico-pathological characterization

31 March 2020

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Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas

31 March 2020

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The prognostic value of invariant chain (Ii) and Her-2/neu expression in curatively resected colorectal cancer

31 March 2020

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Determination of molecular marker expression can predict clinical outcome in colon carcinomas.

31 March 2020

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Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage

31 March 2020

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Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival

31 March 2020

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Prognostic significance of DCC and p27Kip1 in colorectal cancer

31 March 2020

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Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.

31 March 2020

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Loss of p27 expression and microsatellite instability in sporadic colorectal cancer.

31 March 2020

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Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgery

31 March 2020

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Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma

31 March 2020

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Preoperative p27 status is an independent predictor of prostate specific antigen failure following radical prostatectomy

31 March 2020

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Biological correlates of p27 compartmental expression in prostate cancer.

31 March 2020

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Predicting biochemical recurrence after radical prostatectomy for patients with organ-confined disease using p27 expression

31 March 2020

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Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors

31 March 2020

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Cyclin-dependent kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer

31 March 2020

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Expression of p27kip1 in breast cancer and its prognostic significance

31 March 2020

1 reference

Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma

31 March 2020

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p27kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up

31 March 2020

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p27 expression correlates with short-term, but not with long-term prognosis in breast cancer

31 March 2020

1 reference

Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kip1 expression on tissue microarrays of node negative breast cancer

31 March 2020

1 reference

p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy

31 March 2020

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Prognostic role of p27Kip1 and apoptosis in human breast cancer

31 March 2020

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Prognostic impact of cyclin-dependent kinase inhibitor p27kip1 in node-positive breast cancer

31 March 2020

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Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

31 March 2020

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Expression of cell-cycle regulator p27 is correlated to the prognosis and ER expression in breast carcinoma patients

31 March 2020

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High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin

31 March 2020

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The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer

31 March 2020

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Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patients

31 March 2020

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

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Steroid hormone receptors in breast cancer management

31 March 2020

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Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone: radiotherapeutic effect and prognosis

31 March 2020

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Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

31 March 2020

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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

31 March 2020

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Prognostic and predictive factors for breast cancer: translating technology to oncology

31 March 2020

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Gene expression profiling of breast cancer: a new tumor marker

31 March 2020

1 reference

Expression profiling of colorectal carcinomas using tissue microarrays: cell cycle regulatory proteins p21, p27, and p53 as immunohistochemical prognostic markers in univariate and multivariate analysis

31 March 2020

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Relationship between levels of Skp2 and P27 in breast carcinomas and possible role of Skp2 as targeted therapy

31 March 2020

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Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

31 March 2020

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Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2347

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Dimensions Publication ID

4 August 2017

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