(Q73833543)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

D Hershko

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

G Bornstein

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

O Ben-Izhak

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

A Carrano

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

M M Krausz

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

0 references

publication date

1 May 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

91

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

issue

9

1 reference

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7 November 2019

page(s)

1745-1751

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

7 November 2019

cites work

0 references

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

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Prognostic significance of p27(Kip1) expression in colorectal cancer: a clinico-pathological characterization

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Proteasome-dependent degradation of p27/kip1 in gliomas

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The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

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Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

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Inhibitors of mammalian G1 cyclin-dependent kinases

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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The ubiquitin system

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SCF and Cullin/Ring H2-based ubiquitin ligases

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Identifiers

DOI

10.1002/1097-0142(20010501)91:9<1745::AID-CNCR1193>3.0.CO;2-H

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11335900%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference