(Q40702262)

22 September 2017

title

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest (English)

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22 September 2017

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Kathy Han

6

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author name string

Jiyong Liang

1

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22 September 2017

Judit Zubovitz

2

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22 September 2017

Teresa Petrocelli

3

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22 September 2017

Rouslan Kotchetkov

4

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22 September 2017

Michael K Connor

5

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22 September 2017

Jin-Hwa Lee

7

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22 September 2017

Sandra Ciarallo

8

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22 September 2017

Charles Catzavelos

9

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22 September 2017

Richard Beniston

10

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22 September 2017

Edmee Franssen

11

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22 September 2017

Joyce M Slingerland

12

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22 September 2017

language of work or name

English

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publication date

16 September 2002

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22 September 2017

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22 September 2017

volume

8

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22 September 2017

issue

10

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22 September 2017

page(s)

1153-1160

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Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer

22 September 2017

cites work

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7 January 2021

Transforming growth factor-beta and breast cancer: Transforming growth factor-beta/SMAD signaling defects and cancer

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7 January 2021

G1 phase progression: cycling on cue

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7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

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7 January 2021

New functional activities for the p21 family of CDK inhibitors

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7 January 2021

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1 reference

7 January 2021

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

1 reference

7 January 2021

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

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7 January 2021

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

1 reference

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

7 January 2021

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

7 January 2021

Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

1 reference

7 January 2021

Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma.

1 reference

7 January 2021

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

1 reference

7 January 2021

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

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7 January 2021

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

1 reference

7 January 2021

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

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7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

7 January 2021

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

7 January 2021

14-3-3 proteins: regulation of subcellular localization by molecular interference

1 reference

7 January 2021

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

1 reference

7 January 2021

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

1 reference

7 January 2021

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

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7 January 2021

Regulation of protein transport to the nucleus: central role of phosphorylation

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7 January 2021

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

1 reference

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

7 January 2021

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

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7 January 2021

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

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7 January 2021

The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

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7 January 2021

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

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7 January 2021

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

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7 January 2021

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

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7 January 2021

Isolation and growth of human mammary epithelial cells

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7 January 2021

A human cell line from a pleural effusion derived from a breast carcinoma

1 reference

7 January 2021

Human melanoma: development and progression

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7 January 2021

Nuclear protein import using digitonin-permeabilized cells

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

Identifiers

DOI

10.1038/NM761

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22 September 2017

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