(Q37080006)

18 August 2017

1 reference

title

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer (English)

1 reference

18 August 2017

Dan D Hershko

1

1 reference

PubMed ID

18260093

18 August 2017

language of work or name

English

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publication date

1 April 2008

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18 August 2017

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18 August 2017

112

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18 August 2017

7

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18 August 2017

1415-1424

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A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

18 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

Relation of overexpression of S phase kinase-associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

Principles of CDK regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

p27 expression and gastric carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Prognostic role of p27Kip1 deregulation in colorectal cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Translational control of p27Kip1 accumulation during the cell cycle

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

https://api.crossref.org/works/10.1002%2FCNCR.23317

1 reference

7 January 2021

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

SCF and Cullin/Ring H2-based ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The SCF ubiquitin ligase: an extended look

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Therapeutic anti-cancer targets upstream of the proteasome.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The ubiquitin-proteasome pathway and its role in cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Regulation of the cell cycle by SCF-type ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Significance of skp2 expression in primary breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The expression of the ubiquitin ligase subunit Cks1 in human breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Prognostic impact of Skp2 and p27 in human breast cancer.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Regulation of p27 by S-phase kinase-associated protein 2 is associated with aggressiveness in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Skp2 protein expression in soft tissue sarcomas

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Skp2 is oncogenic and overexpressed in human cancers

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Biological significance of p27 and Skp2 expression in renal cell carcinoma. A systematic analysis of primary and metastatic tumour tissues using a tissue microarray technique

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Inverse relationship between p27/Kip.1 and the F-box protein Skp2 in human astrocytic gliomas by immunohistochemistry and Western blot

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Role of the F-box protein Skp2 in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Prognostic significance of the F-box protein Skp2 expression in diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

High expression of Cks1 in human non-small cell lung carcinomas

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Expression of the ubiquitin ligase subunit cyclin kinase subunit 1 and its relationship to S-phase kinase protein 2 and p27Kip1 in prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Crashing waves of destruction: the cell cycle and APC(Cdh1) regulation of SCF(Skp2).

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

F-box protein Skp2: a novel transcriptional target of E2F.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

A bioactive withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression.

1 reference

https://api.crossref.org/works/10.1002%2FCNCR.23317

7 January 2021

Identifiers

DOI

10.1002/CNCR.23317

1 reference

18 August 2017

1 reference

PubMed ID

18260093