(Q44126746)

30 November 2017

ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1. (English)

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30 November 2017

4

Richard G Pestell

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30 November 2017

James Hulit

1

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30 November 2017

Richard J Lee

series ordinal

2

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30 November 2017

Robert G Russell

series ordinal

3

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30 November 2017

language of work or name

English

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publication date

1 September 2002

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30 November 2017

Biochemical Pharmacology

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30 November 2017

64

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30 November 2017

5-6

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30 November 2017

827-836

1 reference

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

30 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptor tyrosine kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Signal transduction in mammary tumorigenesis: a transgenic perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Genomic analysis of metastasis reveals an essential role for RhoC

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Mechanisms and consequences of activation of protein kinase B/Akt

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

The retinoblastoma protein and cell cycle control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Angiotensin II activation of cyclin D1-dependent kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Fos family members induce cell cycle entry by activating cyclin D1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Induction of cyclin D1 by simian virus 40 small tumor antigen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Physical interaction of the retinoblastoma protein with human D cyclins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Histone acetylation and the cell-cycle in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

CDK-independent activation of estrogen receptor by cyclin D1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

A novel cyclin encoded by a bcl1-linked candidate oncogene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

7 January 2021

Cyclin D and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Function of a human cyclin gene as an oncogene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Specific protection against breast cancers by cyclin D1 ablation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Protein kinase Cdelta inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

The ubiquitin-mediated proteolytic pathway as a therapeutic area

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901145-0

10.1016/S0006-2952(02)01145-0

7 January 2021

Identifiers

DOI

1 reference

30 November 2017

1 reference