(Q50287351)

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Long-range resection of DNA DSBs by EXO1 or DNA2

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5685994)

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8 July 2022

Processing of DNA double-strand break ends

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5685994

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8 July 2022

3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]

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8 July 2022

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8 July 2022

3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]

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8 July 2022

2'-deoxyribonucleoside triphosphate

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8 July 2022

3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]

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8 July 2022

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

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8 July 2022

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

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8 July 2022

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

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8 July 2022

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

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8 July 2022

DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells

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8 July 2022

FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response

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8 July 2022

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

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8 July 2022

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

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8 July 2022

FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner

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8 July 2022

DNA end resection by CtIP and exonuclease 1 prevents genomic instability

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8 July 2022

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

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8 July 2022

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q50287351)

Long-range resection of DNA DSBs by EXO1 or DNA2

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