(Q45314240)

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Processing of DNA double-strand break ends

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5693607)

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8 July 2022

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5693607

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8 July 2022

PIAS4 SUMOylates MDC1

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8 July 2022

RNF4 ubiquitinates MDC1

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8 July 2022

SIRT6 deacetylates RBBP8

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8 July 2022

MRN complex binds CDK2 and RBBP8

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8 July 2022

CDK2 phosphorylates RBBP8

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8 July 2022

ATM phosphorylates RBBP8

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8 July 2022

BRCA1 binds phosphorylated RBBP8

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8 July 2022

Initial resection of double-strand break ends

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8 July 2022

EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment

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8 July 2022

Long-range resection of DNA DSBs by EXO1 or DNA2

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8 July 2022

Association of RPA complexes with ssDNA at resected DNA DSBs

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8 July 2022

Binding of ATR:ATRIP to RPA at resected DNA DSBs

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8 July 2022

ATR activation at DNA DSBs

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8 July 2022

ATR phosphorylates RPA2

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8 July 2022

CHEK1 is recruited to resected DNA DSBs

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8 July 2022

Activation of CHEK1 at resected DNA DSBs

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8 July 2022

PPP4C:PPP4R2 dephosphorylates RPA2

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8 July 2022

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling

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8 July 2022

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

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8 July 2022

DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells

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8 July 2022

Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection

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8 July 2022

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

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8 July 2022

The DNA Damage Response: Making It Safe to Play with Knives

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8 July 2022

The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair

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8 July 2022

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.

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8 July 2022

CtIP tetramer assembly is required for DNA-end resection and repair

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8 July 2022

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

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8 July 2022

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45314240)

Processing of DNA double-strand break ends

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