(Q50287358)

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Activation of CHEK1 at resected DNA DSBs

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5684887)

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8 July 2022

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8 July 2022

Processing of DNA double-strand break ends

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5684887

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8 July 2022

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8 July 2022

ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]

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8 July 2022

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8 July 2022

ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]

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8 July 2022

p-S317,S345-CHEK1 [nucleoplasm]

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8 July 2022

p-T916,S945-CLSPN [nucleoplasm]

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8 July 2022

TIMELESS:TIPIN [nucleoplasm]

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8 July 2022

ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]

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8 July 2022

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

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8 July 2022

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling

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8 July 2022

Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response

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8 July 2022

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress

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8 July 2022

Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

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8 July 2022

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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8 July 2022

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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8 July 2022

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

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8 July 2022

Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress

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8 July 2022

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q50287358)

Activation of CHEK1 at resected DNA DSBs

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