(Q50287462)

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MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5358513)

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8 July 2022

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5358513

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8 July 2022

MSH2:MSH3:ADP [nucleoplasm]

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8 July 2022

MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more [nucleoplasm]

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8 July 2022

hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

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8 July 2022

Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha

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8 July 2022

Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities

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8 July 2022

Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops

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8 July 2022

MutSbeta exceeds MutSalpha in dinucleotide loop repair

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8 July 2022

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair

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8 July 2022

hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci

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8 July 2022

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q50287462)

MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

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