(Q50288616)

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Binding of CBL to ligand-responsive p-6Y-EGFR mutants

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-1225949)

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8 July 2022

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-1225949

1 reference

8 July 2022

2

object of statement has role

1 reference

8 July 2022

Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition

1 reference

8 July 2022

EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer

1 reference

8 July 2022

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

1 reference

8 July 2022

Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized

1 reference

8 July 2022

EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

1 reference

8 July 2022

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

1 reference

8 July 2022

Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.

1 reference

8 July 2022

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

1 reference

8 July 2022

Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50288616)

Binding of CBL to ligand-responsive p-6Y-EGFR mutants

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