Wikidata

(Q21171522)

English

cbl proto-oncogene

mammalian protein found in Homo sapiens

  • signal transduction protein CBL
  • Cbl proto-oncogene, E3 ubiquitin protein ligase
  • oncogene CBL2
  • RING-type E3 ubiquitin transferase CBL
  • fragile site, folic acid type, rare, fra(11)(q23.3)
  • CBL
  • E3 ubiquitin-protein ligase CBL
  • proto-oncogene c-Cbl
  • RING finger protein 55
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • casitas B-lineage lymphoma proto-oncogene
  • Proto-Oncogene Proteins c-cbl
In more languages

Statements

molecular function
protein binding
determination method
IPI
53 references
retrieved
8 April 2019
stated in
Stability of diluted solutions of peracetic acid
GOA
curator
UniProt
UniProt protein ID
P22681
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
GOA
curator
UniProt
UniProt protein ID
P22681
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling
GOA
curator
UniProt
UniProt protein ID
P22681
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Threshold-controlled ubiquitination of the EGFR directs receptor fate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Dab2 links CIN85 with clathrin-mediated receptor internalization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Weak binding to E3 ubiquitin ligase c-Cbl increases EGFRvA protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Charting the molecular network of the drug target Bcr-Abl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Activation-modulated association of 14-3-3 proteins with Cbl in T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
retrieved
8 April 2019
stated in
Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22681
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D050721
subject named as
Proto-Oncogene Proteins c-cbl
0 references
PDB structure ID
 
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