(Q24306128)

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Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment

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scholarly article

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Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment (English)

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epidermal growth factor receptor

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GOA release 2020-03-11

cbl proto-oncogene

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GOA release 2020-03-11

Epidermal growth factor receptor pathway substrate 15

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GOA release 2020-03-11

author name string

Annemieke A de Melker

1

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Gerda van der Horst

2

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Jannie Borst

3

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language of work or name

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publication date

31 December 2004

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Journal of Biological Chemistry

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279

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55465-73

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53

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Cbl signaling networks in the regulation of cell function

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Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

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Ligand-induced clathrin-mediated endocytosis of the keratinocyte growth factor receptor occurs independently of either phosphorylation or recruitment of eps15.

1 reference

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Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

1 reference

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Molecular cloning and characterization of a novel cbl-family gene, cbl-c

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Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

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hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

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A function for monoubiquitination in the internalization of a G protein-coupled receptor.

1 reference

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

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Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation

1 reference

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1 reference

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

1 reference

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Cell biology: the ubiquitin connection.

1 reference

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

1 reference

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based on heuristic

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Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

1 reference

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7 January 2021

based on heuristic

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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

1 reference

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7 January 2021

based on heuristic

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The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.

1 reference

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

1 reference

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7 January 2021

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EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene

1 reference

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7 January 2021

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cbl-3: a new mammalian cbl family protein

1 reference

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based on heuristic

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Beyond the RING: CBL proteins as multivalent adapters

1 reference

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7 January 2021

based on heuristic

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TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

1 reference

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7 January 2021

based on heuristic

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Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

1 reference

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based on heuristic

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A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

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based on heuristic

inferred from DOI database lookup

Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits

1 reference

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based on heuristic

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Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain

1 reference

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based on heuristic

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The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping of Eps15 domains involved in its targeting to clathrin-coated pits.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif

1 reference

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based on heuristic

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Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling

1 reference

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based on heuristic

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Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

1 reference

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based on heuristic

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Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

1 reference

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Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

1 reference

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based on heuristic

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Association and colocalization of Eps15 with adaptor protein-2 and clathrin

1 reference

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7 January 2021

based on heuristic

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AP-2/Eps15 interaction is required for receptor-mediated endocytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Monoubiquitin carries a novel internalization signal that is appended to activated receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

The structural era of endocytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

eps15, a novel tyrosine kinase substrate, exhibits transforming activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409765200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M409765200

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