(Q50290116)

English

MEN1 binds SMAD2/3:SMAD4 heterotrimer

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2186643)

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Statements

biological process

1 reference

8 July 2022

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2186643

1 reference

8 July 2022

1

object has role

1 reference

8 July 2022

p-2S-SMAD2,3:SMAD4 [nucleoplasm]

1

object has role

1 reference

8 July 2022

p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm]

1

object has role

1 reference

8 July 2022

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling

1 reference

8 July 2022

Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1).

1 reference

8 July 2022

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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