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AKT phosphorylates TSC2, inhibiting it
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-198609)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
protein kinase B signaling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
part of
TP53 Regulates Metabolic Genes
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
AKT phosphorylates targets in the cytosol
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
exact match
https://identifiers.org/reactome:R-HSA-198609
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
has part(s)
ATP(4-)
quantity
2
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
TSC complex subunit 2
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
ADP(3-)
quantity
2
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
p-S939,T1462-TSC2 [cytosol]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
p-T,p-S-AKT [cytosol]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
cites work
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
Identifiers
Reactome ID
R-HSA-198609
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-198609
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