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STIM1 activation of CRAC
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-434700)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
part of
Elevation of cytosolic Ca2+ levels
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
exact match
https://identifiers.org/reactome:R-HSA-434700
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
has part(s)
ORAI dimer [plasma membrane]
quantity
2
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
STIM1 Dimer [endoplasmic reticulum membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
CRAC channel [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
cites work
Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
Identifiers
Reactome ID
R-HSA-434700
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-434700
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