(Q45316953)

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Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-983695)

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8 July 2022

Signaling by the B Cell Receptor (BCR)

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https://identifiers.org/reactome:R-HSA-983695

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Calcium binds calmodulin

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STIM1 activation of CRAC

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CRAC translocates calcium from the extracellular region to the cytosol

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The Immunoglobulin of the BCR binds antigen

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LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)

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SYK binds the activated BCR

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SYK autophosphorylates at the activated BCR

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p-6Y-SYK phosphorylates BLNK (SLP65)

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BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

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CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

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BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

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IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

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IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol

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STIM1 binds TRPC1 forming STIM1:TRPC1 complex

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TRPC1 translocates calcium from the extracellular region to the cytosol

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Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

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BTK autophosphorylates

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p-SYK and LYN phosphorylate BTK

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p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta)

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Phosphorylated BTK phosphorylates PLCG2

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CD19 is phosphorylated

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p-CD19:VAV binds PI3K and GRB2

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PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated

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p-DAPP1 (p-BAM32) binds PLCG2

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BTK binds BTK inhibitors

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Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes

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Phospholipase C-gamma 1 and phospholipase C-gamma 2 are substrates of the B cell antigen receptor associated protein tyrosine kinase

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Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers

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Surface markers of human lymphocytes

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Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin

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Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement

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Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase

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Early events in B cell activation

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Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

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Tyrosine-phosphorylated forms of Ig beta, CD22, TCR zeta and HOSS are major ligands for tandem SH2 domains of Syk

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Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

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Src-family kinases in B-cell development and signaling

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Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes

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BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins

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Occurrence of surface IgM, IgD, and free light chains of human lymphocytes

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Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells

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Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.

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The Src, Syk, and Tec family kinases: distinct types of molecular switches

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Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation

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Molecular mechanism of the Syk activation switch

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STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

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Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex

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BLNK: a central linker protein in B cell activation

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Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor

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Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta

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Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking

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BLNK mediates Syk-dependent Btk activation

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Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

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Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling

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Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes

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Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

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Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation

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B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia

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A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase

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Purification and characterization of human Syk produced using a baculovirus expression system

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Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry

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Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate

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8 July 2022

Identifiers

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8 July 2022

(Q45316953)

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

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