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(Q50291708)
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SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5684248)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
part of
MAP3K8 (TPL2)-dependent MAPK1/3 activation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
exact match
https://identifiers.org/reactome:R-HSA-5684248
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
has part(s)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
cites work
Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
Identifiers
Reactome ID
R-HSA-5684248
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5684248
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