(Q50291778)

English

Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-975103)

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Statements

biological process

1 reference

8 July 2022

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-975103

1 reference

8 July 2022

6

object has role

1 reference

8 July 2022

p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]

1

object has role

1 reference

8 July 2022

6

object has role

1 reference

8 July 2022

p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane]

1

object has role

1 reference

8 July 2022

TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop

1 reference

8 July 2022

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

1 reference

8 July 2022

Essential function for the kinase TAK1 in innate and adaptive immune responses.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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