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English
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-975163)
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Statements
instance of
biological pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
part of
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
exact match
https://identifiers.org/reactome:R-HSA-975163
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
has part(s)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
cites work
Distinct molecular mechanism for initiating TRAF6 signalling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
Identifiers
Reactome ID
R-HSA-975163
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-975163
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