(Q45317009)

English

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-975138)

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Statements

biological pathway

1 reference

8 July 2022

MyD88 dependent cascade initiated on endosome

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-975138

1 reference

8 July 2022

TAK1-dependent IKK and NF-kappa-B activation

1 reference

8 July 2022

MAP kinase activation

1 reference

8 July 2022

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

1 reference

8 July 2022

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

1 reference

8 July 2022

TRAF6 binds MEKK1

1 reference

8 July 2022

Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex

1 reference

8 July 2022

The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation

1 reference

8 July 2022

Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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