(Q50291804)

English

Activated TLR2/4 interacts with MAL (TIRAP)

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2201316)

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1 reference

8 July 2022

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2201316

1 reference

8 July 2022

Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

TIRAP:PI(4,5)P2 [plasma membrane]

quantity

2

object of statement has role

1 reference

8 July 2022

TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

1 reference

8 July 2022

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

1 reference

8 July 2022

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

1 reference

8 July 2022

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50291804)

Activated TLR2/4 interacts with MAL (TIRAP)

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