(Q45317019)

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MyD88:MAL(TIRAP) cascade initiated on plasma membrane

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-166058)

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Statements

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8 July 2022

MyD88-dependent toll-like receptor signaling pathway

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8 July 2022

Toll Like Receptor 4 (TLR4) Cascade

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8 July 2022

Toll Like Receptor TLR1:TLR2 Cascade

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8 July 2022

Toll Like Receptor TLR6:TLR2 Cascade

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-166058

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8 July 2022

TAK1-dependent IKK and NF-kappa-B activation

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8 July 2022

IRAK1 recruits IKK complex

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8 July 2022

IRAK2 mediated activation of TAK1 complex

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8 July 2022

MAP kinase activation

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8 July 2022

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8 July 2022

Activated TLR2/4 interacts with MAL (TIRAP)

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8 July 2022

Activated TLR2/4:TIRAP interacts with BTK

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8 July 2022

TIRAP is phosphorylated by BTK

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8 July 2022

MyD88 forms a complex with TIRAP:activated TLR2/4

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8 July 2022

MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88

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8 July 2022

IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex

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8 July 2022

IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP

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8 July 2022

IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex

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8 July 2022

Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex

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First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal

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8 July 2022

Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP

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8 July 2022

Multiple IRAK1 autophosphorylation steps

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8 July 2022

TRAF6 binds to hp- IRAK1

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8 July 2022

TRAF6 binds to p-IRAK2

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8 July 2022

Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex

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8 July 2022

Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex

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8 July 2022

TIRAP binds PIP2-rich regions in the plasma membrane

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8 July 2022

MD-2: the Toll 'gatekeeper' in endotoxin signalling

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317019)

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

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