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USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5689950)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
part of
Ub-specific processing proteases
1 reference
stated in
Reactome
retrieved
13 July 2022
Reactome ID
R-HSA-5689950
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
exact match
https://identifiers.org/reactome:R-HSA-5689950
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
has part(s)
water
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
PolyUb [nucleoplasm]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
cites work
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
A dynamic role of HAUSP in the p53-Mdm2 pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
Identifiers
Reactome ID
R-HSA-5689950
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5689950
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