(Q50297604)

English

CBL ubiquitinates FRS2 and FGFR2

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5654677)

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Statements

biological process

1 reference

8 July 2022

Negative regulation of FGFR2 signaling

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-5654677

1 reference

8 July 2022

Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]

1

object has role

1 reference

8 July 2022

1

object has role

1 reference

8 July 2022

Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane]

1

object has role

1 reference

8 July 2022

Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane]

1

object has role

1 reference

8 July 2022

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

1 reference

8 July 2022

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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