(Q50298186)

English

STUB1 (CHIP) ubiquitinates SMAD3

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2187368)

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Statements

biological process

1 reference

8 July 2022

Downregulation of TGF-beta receptor signaling

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2187368

1 reference

8 July 2022

SMAD3:STUB1 [cytosol]

1

object has role

1 reference

8 July 2022

1

object has role

1 reference

8 July 2022

STIP1 homology and U-box containing protein 1

1

object has role

1 reference

8 July 2022

Ub-SMAD3 [cytosol]

1

object has role

1 reference

8 July 2022

SMAD3:STUB1 [cytosol]

1

object has role

1 reference

8 July 2022

CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

1 reference

8 July 2022

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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