(Q24298589)

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CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

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scholarly article

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CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation (English)

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STIP1 homology and U-box containing protein 1

1 reference

GOA release 2020-03-11

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GOA release 2020-03-11

4

object named as

Hongxiu Ning

author given names

Hongxiu

author last names

Ning

1 reference

PubMed publication ID

20 April 2024

author name string

Hong Xin

1

author given names

Hong

author last names

Xin

1 reference

PubMed publication ID

20 April 2024

Xialian Xu

2

author given names

Xialian

author last names

Xu

1 reference

PubMed publication ID

20 April 2024

Linyu Li

3

author given names

Linyu

author last names

Li

1 reference

PubMed publication ID

20 April 2024

Yu Rong

5

author given names

Yu

author last names

Rong

1 reference

PubMed publication ID

20 April 2024

Yu Shang

6

author given names

Yu

author last names

Shang

1 reference

PubMed publication ID

20 April 2024

Yinyin Wang

7

author given names

Yinyin

author last names

Wang

1 reference

PubMed publication ID

20 April 2024

Xin-Yuan Fu

8

author given names

Xin-Yuan

author last names

Fu

1 reference

PubMed publication ID

20 April 2024

Zhijie Chang

9

author given names

Zhijie

author last names

Chang

1 reference

PubMed publication ID

20 April 2024

language of work or name

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publication date

27 May 2005

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Journal of Biological Chemistry

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280

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21

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20842-50

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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

How cells read TGF-beta signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Regulation of Smad activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Nomenclature: vertebrate mediators of TGFbeta family signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

The 26S proteasome system in the signaling pathways of TGF-beta superfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Ski/Sno and TGF-beta signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

ErbB2 degradation mediated by the co-chaperone protein CHIP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Protein turnover: a CHIP programmed for proteolysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Smads bind directly to the Jun family of AP-1 transcription factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

21 January 2018

Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

7 January 2021

based on heuristic

inferred from DOI database lookup

Physical and functional interaction of SMADs and p300/CBP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412275200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M412275200

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release_s4pahcrvdjgdtoywzvpzt32i64

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PubMed publication ID

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